نتایج جستجو برای: RNaseA enzyme

تعداد نتایج: 241005  

Gold nanoparticle-based diagnostic methods have attracted much attention due to their simplicity, high sensitivity and low cost. These methods are mostly used for early and efficient detection of various pathogenic factors and assessment of gene expression and nanoparticles stability. In this study, melon plants were cultured in vivo and then, RNA was extracted from leaf explants. A 40 bp probe...

2012
Limin Li Dihan Zhu Lei Huang Jing Zhang Zhen Bian Xi Chen Yuan Liu Chen-Yu Zhang Ke Zen

Cell-secreted miRNAs are highly stable and can serve as biomarkers for various diseases and signaling molecules in intercellular communication. The mechanism underlying the stability of circulating miRNAs, however, remains incompletely understood. Here we show that Argonaute 2 (Ago2) complexes and microvesicles (MVs) provide specific and non-specific protection for miRNA in cell-secreted MVs, r...

Journal: :Journal of bioinformatics and computational biology 2006
Tun-Wen Pai Bo-Han Su Pei-Chih Wu Margaret Dah-Tsyr Chang Hao-Teng Chang Tan-Chi Fan Shi-Hwei Liu

Human ribonuclease A (RNaseA) superfamily consists of eight RNases with high similarity in which RNase2 and RNase3 share 76.7% identity. The evolutionary variation of RNases results in differential structures and functions of the enzymes. To distinguish the characteristics of each RNase, we developed reinforced merging algorithms (RMA) to rapidly identify the unique peptide motifs for each memb...

2017
Oscar Velazquez Camacho Carmen Galan Kalina Swist-Rosowska Reagan Ching Michael Gamalinda Fethullah Karabiber Inti De La Rosa-Velazquez Bettina Engist Birgit Koschorz Nicholas Shukeir Megumi Onishi-Seebacher Suzanne van de Nobelen Thomas Jenuwein

The Suv39h1 and Suv39h2 histone lysine methyltransferases are hallmark enzymes at mammalian heterochromatin. We show here that the mouse Suv39h2 enzyme differs from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic chromatin and provides an additional affinity for major satellite repeat RNA. To analyze an RNA-dependent interaction with chromatin, we purified...

2018
Lior Doron Pierre Goloubinoff Michal Shapira

Photosynthesis is performed by large complexes, composed of subunits encoded by the nuclear and chloroplast genomes. Assembly is assisted by general and target-specific chaperones, but their mode of action is yet unclear. We formerly showed that ZnJ2 is an algal chaperone resembling BSD2 from land plants. In algae, it co-migrates with the rbcL transcript on chloroplast polysomes, suggesting it ...

Journal: :Chemical & pharmaceutical bulletin 2011
Tamae Uchida Takanori Kanazawa Yuuki Takashima Hiroaki Okada

Topical use of small interfering RNA (siRNA) as a therapeutic nucleic acid is increasingly studied for the treatment of skin diseases and for the improvement of skin properties. However, naked siRNA transdermal delivery is limited by its low stability in the body and low permeability into target cells. This is due to various skin barriers such as the stratum corneum that has multiple lipid bila...

2018
Ruijing Geng Han Liu Weimin Wang

Ribonucleases (Rnases)2 and Rnase3 belong to the ribonuclease A (RnaseA) superfamily. Apart from their role in molecular evolutionary and functional biological studies, these genes have also been studied in the context of defense against pathogen infection in mammals. However, expression patterns, structures and response to bacterial infection of the two genes in blunt snout bream (Megalobrama ...

Journal: :Nucleic acids research 2004
Sandra Fouace Cyril Gaudin Sylvie Picard Sophie Corvaisier Jacques Renault Bertrand Carboni Brice Felden

Site-selective scission of ribonucleic acids (RNAs) has attracted considerable interest, since RNA is an intermediate in gene expression and the genetic material of many pathogenic viruses. Polyamine-imidazole conjugates for site-selective RNA scission, without free imidazole, were synthesized and tested on yeast phenylalanine transfer RNA. These molecules catalyze RNA hydrolysis non-randomly. ...

2005
Hao-Teng Chang Tan-Chi Fan Margaret Dah-Tsyr Chang Tun-Wen Pai Bo-Han Su Pei-Chih Wu

Human ribonuclease A (RNase A) superfamily consists of eight RNases with high sequence homology, in which RNase2 and RNase3 share 78% similarity. The evolutionary variation of RNases results in differential structure and function of the enzymes. To distinguish the characteristics of each RNase, we developed reinforced merging algorithms (RMA) to rapidly predict and identify the unique sequence ...

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