نتایج جستجو برای: RB-domains

تعداد نتایج: 185704  

In this paper, we introduce the notion of super finitely separating functions which gives a characterization of RB-domains. Then we prove that FS-domains and RB-domains are equivalent in some special cases by the following three claims: a dcpo is an RB-domain if and only if there exists an approximate identity for it consisting of super finitely separating functions; a consistent join-semilatti...

Journal: :Categories and General Algebraic Structures with Application 2018

Journal: :Aquatic toxicology 2009
Rebeka R Merson Sibel I Karchner Mark E Hahn

The aryl hydrocarbon receptor (AHR) mediates the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. In some mammalian cell lines, TCDD induces G1 cell cycle arrest, which depends on an interaction between the AHR and the retinoblastoma tumor suppressor (RB). Mammals possess one AHR, whereas fishes possess two or more AHR paralogs that differ in the domains import...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Tyler J Liban Edgar M Medina Sarvind Tripathi Satyaki Sengupta R William Henry Nicolas E Buchler Seth M Rubin

The retinoblastoma protein (Rb) and the homologous pocket proteins p107 and p130 negatively regulate cell proliferation by binding and inhibiting members of the E2F transcription factor family. The structural features that distinguish Rb from other pocket proteins have been unclear but are critical for understanding their functional diversity and determining why Rb has unique tumor suppressor a...

2004
Junliang Zhang Tim Shearer Gary Marchionini Miles Efron Jonathan L. Elsas

The system we will demo is an interface called Relation Browser++ (RB++), which is intended to help users explore, browse and search large information collection effectively and efficiently. It is the latest updated version of relational browser (Marchionini & Brunk, 2003). Applications of RB++ in several different domains will be demonstrated, such as library video collection, EIA (Energy info...

Journal: :Cancer research 2001
W Pan S Cox R H Hoess R H Grafström

Phosphorylation of the retinoblastoma protein (Rb) by the cyclin D1/cyclin-dependent kinase (cdk) 4 complex (cdk4/D1) is a key regulatory step for maintaining the orderly progression of the cell cycle. The B domain of Rb contains a site that recognizes and binds the LXCXE motif found in D-type cyclins. This interaction is important for phosphorylation of Rb by cdk4/D1, although in vitro the Rb ...

Journal: :Journal of psychiatric research 2009
Christopher J Hopwood S Alexandra Burt John C Markowitz Shirley Yen M Tracie Shea Charles A Sanislow Carlos M Grilo Emily B Ansell Thomas H McGlashan John G Gunderson Mary C Zanarini Andrew E Skodol Leslie C Morey

Previous research has demonstrated that aggression (AGG) and non-aggressive rule-breaking (RB) represent elements of antisocial behavior with different etiological mechanisms and associations to personality and psychopathology. However, these constructs have not been investigated in an adult clinical sample. In the current study, interview and self-report derived AGG and RB were associated with...

Journal: :acta medica iranica 0
mohamad reza haji amousha department of pathology, shariati hospital, tehran university of medical sciences, tehran, iran. nastaran sabetkish school of medicine, tehran university of medical sciences, tehran, iran. nastaran sabet kish school of medicine, tehran university of medical sciences, tehran, iran. ramin heshmat department of epidemiology and biostatistic, endocrine and metabolism research center, shariati hospital, tehran university of medical sciences, iran. afsaneh rajabiani department of pathology, shariati hospital, tehran university of medical sciences, tehran, iran. hiva saffar department of pathology, shariati hospital, tehran university of medical sciences, tehran, iran.

the distinction between malignant and benign pheochromocytoma has always been a diagnostic challenge over the last decades. to date, the only reliable criterion is metastasis. the aim of the present study was to investigate the possible expression of pituitary-tumor transforming gene (pttg1) and retinoblastoma (rb) in benign and malignant pheochromocytoma. paraffin blocks of 44 and 11 patients ...

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