Nuclear medicine imaging has been used to localize infection sites and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [99mTc (CO)3 (H2O)3]+ core in order to evaluate its feasibility as an infection imaging agent for in vivo use. The stability of radioconjugate was checked in ...

Nuclear medicine imaging has been used to localize infection sites and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [99mTc (CO)3 (H2O)3]+ core in order to evaluate its feasibility as an infection imaging agent for in vivo use. The stability of radioconjugate was checked in ...

Secondary ion mass spectrometry (SIMS) and confocal Raman microscopy (CRM) are combined to analyze the chemical composition of cultured Pseudomonas aeruginosa biofilms, providing complementary chemical information for multiple analytes within the sample. Precise spatial correlation between SIMS and CRM images is achieved by applying a chemical microdroplet array to the sample surface which is u...

ABSTRACT- The aim of this study was to determine the quinolone residues in beef and chicken meat samples collected from Urmia region local markets.A total of 395 beef and chicken meat samples varied in three various brands were analyzed in Urmia, Iran by using a sensitive and reliable analytic method based on ELISA detection, for quantification of quinolone antibiotics residues. Samples prepara...

Quinolone antibiotics have been commonly used to treat cases of multiple antibiotic resistance. Unfortunately, quinolone so much resisted by infectious bacterial agents. This study aimed evaluate the susceptibility some clinical isolates E. coli and determination plasmid-encoded resistance genes.
 Our results showed plasmid quinolone-resistance genes in following prevalence: qnr genes: S (...

The prevalence of quinolone- and macrolide-resistant Group B Streptococcus (GBS) is increasing worldwide, but the relationship between resistance GBS to these antibiotics patient outcome remains unclear. Therefore, we evaluated whether blood stream infection caused by or associated with high mortality. Our findings in 77 patients bacteremia demonstrate that quinolone macrolide may not be risk f...

Quinolone antibacterials are one of the most important classes of pharmacological agents known as potent inhibitors of bacterial DNA gyrase and topoisomerase IV that efficiently inhibit DNA replication and transcription by generating several double-stranded DNA break. Some quinolone derivatives demonstrated inhibitory potential against eukaryote topoismarase II and substantial dose-dependent cy...

The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 7...

  Quinolone antibacterial agents are currently used for the treatment of various bacterial infections. The nature of functional group at the 7 position of the quinolone ring system is known to have strong influence on the spectrum and extent of in vitro antibacterial activity. Accordingly, a series of N-L2- oxo-2-(2- furyl) and N-[2- oxyimino (2- furyl) ethyl] piperazinyl quinolone derivatives...

quinolone antibacterials are one of the most important classes of pharmacological agents known as potent inhibitors of bacterial dna gyrase and topoisomerase iv that efficiently inhibit dna replication and transcription by generating several double-stranded dna break. some quinolone derivatives demonstrated inhibitory potential against eukaryote topoismarase ii and substantial dose-dependent cy...