nicotine-based ionic liquid has been used as a green catalyst for pyridine-catalyzed huisgen reaction. it promoted addition of dimethylacetylenedicarboxylate to aldehydes or n-tosyl imines leading to efficient synthesis of 2-benzoylfumarates and 1-azadienes respectively under pyridine free odorless ionic liquid conditions. the improved results were obtained in terms of enhanced yields, with min...

Nicotine-based ionic liquid has been used as a green catalyst for pyridine-catalyzed Huisgen reaction. It promoted addition of dimethylacetylenedicarboxylate to aldehydes or N-tosyl imines leading to efficient synthesis of 2-benzoylfumarates and 1-azadienes respectively under pyridine free odorless ionic liquid conditions. The improved results were obtained in terms of enhanced yields, with min...

Nicotine-based ionic liquid has been used as a green catalyst for pyridine-catalyzed Huisgen reaction. It promoted addition of dimethylacetylenedicarboxylate to aldehydes or N-tosyl imines leading to efficient synthesis of 2-benzoylfumarates and 1-azadienes respectively under pyridine free odorless ionic liquid conditions. The improved results were obtained in terms of enhanced yields, with min...

An α-[Cu(II)-porphyrin]-polyethylene was synthesized for the first time using copper catalyzed 1,3-dipolar azide-alkyne Huisgen cycloaddition yielding highly colored moiety-substituted polyethylene.

In this protocol, we report a novel approach for the synthesis of a new class of heterocyclic 1H-1,2,3-triazole-modified peptidomimetic compounds. The process consists of an Ugi four-component condensation reaction of amines, an isocyanide, an aldehyde and acids followed by a Huisgen 1,3-dipolar cycloaddition reaction with an azide group in the presence of a catalytic amount of CuSO4</...

SN2 rection between 4-(tert-butyldimethylsilyl)hex-5-yn-1-yl 4-methylbenzenesulfonate and NaN3 in DMF at 80 °C provided (6-azidohex-1-yn-3-yl)(tert-butyl)dimethylsilane intermediate, which underwent situ intramolecular thermal Huisgen azide–alkyne cycloaddition reaction. This one-pot process gave 4-(tert-butyldimethylsilyl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridine 78% yield.

An intramolecular Huisgen cycloaddition of an interconverting set of isomeric allylic azides with alkynes affords substituted triazoles in high yield. The stereoisomeric vinyl-substituted triazoloxazines formed depend on the rate of cycloaddition of the different allylic azide precursors when the reaction is carried out under thermal conditions. In contrast, dimerized macrocyclic products were ...

The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition 4-azido-7-chloroquinoline with an alkyne derivative acetaminophen. compound was fully characterized Fourier-transform infrared (FT...

Two-dimensional (2D) nanomaterials have gained considerable attention due to their unique structural and physicochemical properties. Herein, we synthesized 2D crystalline cellulose oligomers with surface-reactive azide groups through enzymatic reactions and covalently post-functionalized them with 1-ethynyl pyrene through copper(i)-catalyzed Huisgen cycloaddition reactions.

Optically active polymers containing P-stereogenic bisphosphine and 1,2,3-triazole units in the main chain were obtained by copper-catalyzed Huisgen cycloaddition. The repeating unit of the polymer adopted bidentate as well as tetradentate coordination, leading to the change in the conformations of the polymer via complexation with transition metals.