colchicine, a potent neurotoxin derived from plants, has been recently introduced as a degenerative toxin of small pyramidal cells in the cortical area 1 of the hippocampus (ca1). in this study, the effect of the alkaloid in ca1 on the behaviors in the conditioning task was measured. injections of colchicine (1,5 μg/rat, intra-ca1) was performed in the male wistar rats, while the animals were s...

background and objectives: study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. in this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (ca1) was examined by the studying the hippocampal tissue. materials and methods: injections of colchicine (1-75 μg/rat, intra- hippocampal ca1) were performed in cannulated male wistar rat...

the mechanism by which lead may cause a perturbotion in the nevous system is through the nitric oxide synthase. in this study the effect of lead acetate on the hippocampal constitutive nitric oxide production was studied. the variation in the nitric oxide production may contribute to physiological lead neurotoxicity in vivo. different concentrations of lead acetate (10-9 to 10-6 m), wre added t...

chronic exposure to lead (pb) affects neural functions in central nervous system (cns) particularly the learning and memory. on the other hand, alteration of calcium level in the cns results in activation of nos. it has been shown that lead enters the neurons through calcium channels and displaces ca2+ from calcium binding proteins such as calmodulin and troponin c thereby affecting calcium-med...

objective(s):the hippocampus has been implicated in pathophysiology of schizophrenia. prenatal stress is a contributing risk factor for a wide variety of neuropsychiatric diseases including schizophrenia. this study examined long-term effects of prenatal restraint stress on the stereological parameters in the cornu ammonis (ca) of adult male rats as an animal model of schizophrenia. materials a...

introduction: (s)- 3,5-dihydroxyphenylglycine (dhpg) is an agonist for group i metabotropic glutamate receptors. dhpg-induced synaptic depression of excitatory synapses on hippocampal pyramidal neurons is well known model for synaptic plasticity studies. the aim of the present study was to examine the effects of dhpg superfusion on excitatory synapses on pyramidal and fast-spiking gabaergic cel...

introduction: many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal ca1 region. however, cellular mechanisms...

Introduction: (S)- 3,5-Dihydroxyphenylglycine (DHPG) is an agonist for group I metabotropic glutamate receptors. DHPG-induced synaptic depression of excitatory synapses on hippocampal pyramidal neurons is well known model for synaptic plasticity studies. The aim of the present study was to examine the effects of DHPG superfusion on excitatory synapses on pyramidal and fast-spiking GABAergic cel...

Objective(s):The hippocampus has been implicated in pathophysiology of schizophrenia. Prenatal stress is a contributing risk factor for a wide variety of neuropsychiatric diseases including schizophrenia. This study examined long-term effects of prenatal restraint stress on the stereological parameters in the Cornu Ammonis (CA) of adult male rats as an animal model of schizophrenia. Materials ...

objective(s):global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in ca1 region of hippocampus. in this study, we investigated the possible neuroprotective effects of the ethanol extract of cyperus rotundus (eecr) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. materials and methods: treatment ...