in spite of the existing reports on behavioural and biochemical changes related to the cerebellum due to noise stress, not much is known about the effect of noise stress on the neuronal changes in the cerebellum. the present study aims at investigating the effects from one week noise exposure on granule cell number and purkinje cell volume within the neonate rat cerebellum. 15-day-old male wist...

introduction: diabetes mellitus is associated with nervous system alterations in both human and animal models. this study was done to determine the effect of gestational diabetes on the purkinje and granular cells in the cerebellum of rat offspring.  methods: 10 wistar rats dams were randomly allocated in control and diabetic group. the experimental group received 40 mg/kg/body weight of strept...

Introduction: Beta-carboline alkaloids of P. harmala are shown to have immune-modulatory effects in several studies. Extracts of this plant have significant anti-inflammatory effect via the inhibition of some inflammatory mediators including PGE2 and TNF-α. In postmortem studies, structural alterations to the cerebellum have been recognized, including Purkinje cell loss being re...

Objective(s) The purpose of this study was to investigate the role of oxidative stress in Purkinje cell neurotoxicity ofethanol-treated rat. Materials and Methods Male rat pups 4-day-old was used in this study. Ethanol was administered to rat pups at a dose of 6 g/kg from postnatal days (PDs) 4 to 5.  Pups were killed 90 min after the second alcohol treatment on PD 5 by decapitation and the ...

objective(s) the purpose of this study was to investigate the role of oxidative stress in purkinje cell neurotoxicity ofethanol-treated rat. materials and methods male rat pups 4-day-old was used in this study. ethanol was administered to rat pups at a dose of 6 g/kg from postnatal days (pds) 4 to 5.  pups were killed 90 min after the second alcohol treatment on pd 5 by decapitation and the bra...

In spite of the existing reports on behavioural and biochemical changes related to the cerebellum due to noise stress, not much is known about the effect of noise stress on the neuronal changes in the cerebellum. The present study aims at investigating the effects from one week noise exposure on granule cell number and Purkinje cell volume within the neonate rat cerebellum.15-day-old male Wista...

objective: the purpose of this study was to investigate the role of fast inactivating (ia) voltage dependent potassium channels in shaping the discharge activity of cerebellar purkinje cells (pcs) in ataxic rats. materials and methods: male sprauge-dawley rats (40-60 g) were used in this study. ataxia was induced via single i.p. injection of 3-acethylpyridine (65 mg/kg). four days following ind...

background: learning and memory are the most intensively studied subjects in neuroscience. two sites of mammalian brain which are important in learning and memory are ca1 region of hippocampus and purkinje cell layer of cerebellum. so, the aim of present investigation was to study of the effect of ovariectomy and passive avoidance learning on nr1 subunit of n-methyl-d-aspartate (nmda) receptor ...

We report on a rare case of paraneoplastic syndrome (PS) that was discovered completion diagnostic work up to be fallopian tube carcinoma. A 65year old female, presented with 1 month history imbalance, gait instability, incoordination right upper limb, vertigo and vomiting. Cerebrovascular accident drug intoxication excluded. Indicative further diagnosis presence adnexal mass in pelvis identifi...

Structural changes in Purkinje cells have been identified in the essential tremor cerebellum, although the mechanisms that underlie these changes remain poorly understood. Climbing fibres provide one of the major excitatory inputs to Purkinje cells, and climbing fibre-Purkinje cell connections are essential for normal cerebellar-mediated motor control. The distribution of climbing fibre-Purkinj...