The Holmes-Adie syndrome consists of pupillotonia, arreflexia and autonomic dysfunction. Some explanations for these different symptoms have been attempted, centred upon neuropathological and electrophysiological findings. A hypothetical immunemediated mechanism, as in the Guillain Barré syndrome, is presented in this paper for explaining the three chief symptoms of the syndrome.

an 8-year-old female japanese spitz dog was reffered to shiraz university veterinary clinic, with signof anisocoria. clinical examinations revealed mydriasis in the right eye. ocular examination revealed adilated and unresponsive right pupil to focal illumination. by testing with topical 2% pilocarpine, thetentative diagnosis was parasympathetic denervation of the right iris sphincter muscle—pu...

An 8-year-old female Japanese Spitz dog was reffered to Shiraz University Veterinary Clinic, with signof anisocoria. Clinical examinations revealed mydriasis in the right eye. Ocular examination revealed adilated and unresponsive right pupil to focal illumination. By testing with topical 2% pilocarpine, thetentative diagnosis was parasympathetic denervation of the right iris sphincter muscle—pu...

Darkness pupil diameters, light reflexes, and redilatation times have been recorded with infrared TV pupillometry in 12 consecutive patients with systemic amyloidosis associated with sensory motor and autonomic neuropathy. Nine of the patients had AL amyloidosis, two had familial amyloidosis associated with a transthyretin abnormality, and one was untyped. The pupils were abnormal in all 12 pat...

Widely varying pupillary abnormalities are in clinical practice often grouped under the heading of the Holmes-Adie syndrome. Adie (1932) described the complete form of the disorder as comprising the typical tonic pupil, with its characteristic delayed reaction to convergence and the loss of some of the tendon reflexes, whereas in the incomplete form he included those cases in which the reflexes...