backround laryngopharyngeal reflux (lpr) is the backflow of stomach contents above upper esophageal sphincter, into the pharynx, larynx, and upper aerodigestive system. objectives in this study, effects of omeprazole over voice quality in muscle tension dysphonia with laryngopharyngeal reflux was ınvestigated. patients and methods nine patients, 7 males and 2 females, aged between 27-43 (mean a...

conclusions the occurrence of he is associated with hyponatremia and ppi use in patients with aclf. results in univariate analysis, patients with he in aclf had a significantly higher rate of ppi use (89.1%) compared with non-he (63.6%, p = 0.001). in addition, clinical and standard laboratory variables were significantly different between the two groups regarding the infection rate, hyponatrem...

objective(s):pantoprazole, is a proton pump inhibitor (ppi) prescribed for the treatment of upper gastrointestinal disorders, which in high doses has been suggested to decrease calcium absorption leading to hypocalcaemia and therefore osteoporosis. the aim of this study was to assess whether pantoprazol, could alter the rate of orthodontic tooth movement (otm) in rats. materials and methods: a ...

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gastro-esophageal reflux disease (gerd) regularly occurs when stomach acid moves up from the stomach into the esophagus. gerd might be associated with chronic asthma symptoms such as coughing and breathlessness. according to several studies on children and adults, gerd is proven to have a close relationship with asthma.  medication treatment via proton-pump inhibitors (ppis), such as omeprazole,...

background helicobacter pylori diagnostic tests can be affected by different interventional factors. we studied the effects of smoking, proton pump inhibitors (ppis) and antibiotic administration on results of the bacterial culture, and its diagnosis tests due to polymerase chain reaction (pcr) and rapid urease test (rut) methods. objectives this study was aimed to investigate the undesirable e...

background: combination antiplatelet therapy is a classic treatment for percutaneous coronary intervention (pci) but this therapy increases gastrointestinal bleeding (gib). this study highlights the incidence of related risk factors of gib and endoscopic findings in patients with gib after pci and combination antiplatelet therapy. materials and methods: a standard check list was used to evaluat...

OBJECTIVE To study the prescribing pattern of proton pump inhibitors with regard to the time of dosing. DESIGN Retrospective study. SETTING Private hospital, Hong Kong. PATIENTS All patients prescribed three specific proton pump inhibitors from 1 January to 31 July 2006 were included. MAIN OUTCOME MEASURES For all three proton pump inhibitors, the prescribed dosing instructions were rec...

Proton pump inhibitors inhibit the gastric H+/K+-ATPase via covalent binding to cysteine residues of the proton pump. All proton pump inhibitors must undergo acid accumulation in the parietal cell through protonation, followed by activation mediated by a second protonation at the active secretory canaliculus of the parietal cell. The relative ease with which these steps occur with different pro...