objective(s): mutant forms fms-like tyrosine kinase-3 (flt3), are reported in 25% of childhood acute lymphoid leukemia (all) and 30% of acute myeloid leukemia (aml) patients. in this study, drug response, growth promoting, and protein trafficking of flt3 wild-type was compared with two active mutants (internal tandem duplication (itd)) and d835y. materials and methods:flt3 was expressed on fact...

membrane/ protein trafficking in the secretory/ biosynthetic and endocytic pathways is mediated by vesicles. vesicle trafficking in eukaryotes is regulated by a class of small monomeric gtpases the rab protein family. rab proteins represent the largest branch of the ras superfamily gtpases, and have been concerned in a variety of intracellular vesicle trafficking and different intracellular sig...

Membrane/ protein trafficking in the secretory/ biosynthetic and endocytic pathways is mediated by vesicles. Vesicle trafficking in eukaryotes is regulated by a class of small monomeric GTPases the Rab protein family. Rab proteins represent the largest branch of the Ras superfamily GTPases, and have been concerned in a variety of intracellular vesicle trafficking and different intracellular sig...

The herpes simplex virus type 1 (HSV-1) tegument protein, VP22 has been reported to have the property of intercellular transport. The previous studies have shown that following expression of a fusion protein containing VP22 it spreads to every cell in a monolayer and concentrates in the nucleus. In spite of these reports, some studies have shown that VP22 trafficking and its nucleus accumulatio...

To elucidate the regulation of serotonin transporter (SERT) function via its membrane trafficking, we investigated involvement ubiquitin E3 ligase HRD1 (HMG-CoA reductase degradation protein), which participates in endoplasmic reticulum (ER)-associated (ERAD), functional SERT. Cells transiently expressing wild-type SERT or a C-terminal deletion mutant (SERTΔCT), protein predicted to be misfolde...

human trafficking is one form of organized crime with 7 to 10 billion dollars profit next to drug and weapon trades. former soviet republics and eastern europe have become the newest sources of human trafficking, for europe and north america for the purpose of sexual exploitation .this article is a result in causes of human trafficking in central asian republic of the former soviet :union:.

Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles (SV) and released at the active zone (AZ). While recent years major progress has been made unraveling molecular machinery responsible for SV docking, fusion exocytosis, mechanisms governing AZ protein trafficking through axons still remain unclear. Here, we performed stop-flow nerve ligation to examine a...

the herpes simplex virus type 1 (hsv-1) tegument protein, vp22 has been reported to have the property of intercellular transport. the previous studies have shown that following expression of a fusion protein containing vp22 it spreads to every cell in a monolayer and concentrates in the nucleus. in spite of these reports, some studies have shown that vp22 trafficking and its nucleus accumulatio...