BACKGROUND Patients dialyzed with equal eKt/V may have huge variations in their urea concentrations. METHODS Urea generation rate, distribution volume and renal clearance were determined in 205 hemodialysis sessions of 33 patients with double pool urea kinetic modeling using dialyzer clearance from online monitoring. From these data, optimized prescriptions were computed. RESULTS In simulat...

Nine malnourished and nine children who had recovered from malnutrition were given a single injection of albumin-(131)I and were studied during consecutive periods in which the dietary protein was changed.Malnourished children had significantly lower catabolic rates of albumin than had recovered children on the same protein intake. Both nutritional groups, however, showed a progressive fall in ...

Myofibrillar protein catabolic rate was calculated in seven patients with Duchenne muscular dystrophy from the amount of 3-methylhistidine excreted in the urine, and found to be over three times that found in a control series when expresses as the percentage of myofibrillar protein catabolised per day. It is suggested that measurement of myofibrillar protein catabolic rate may add a useful para...

Fractional catabolic rates of iodine-labeled plasma albumins and fibrinogens have been measured in experiments of a few hours duration in adult rabbits. The method used which is based on release of labeled iodide from the protein gives accurate estimates of catabolic rates (expressed as fractions of the plasma protein pool catabolized per day) after 36 hr without the need for urine collections....