نتایج جستجو برای: Pronephros
تعداد نتایج: 272 فیلتر نتایج به سال:
An understanding of the regulation of kidney development has increased dramatically in the past decade. The pronephros, mesonephros, and metanephros represent three distinct renal organs that function, in succession, as the vertebrate excretory system during development of the kidney. These three organ systems are derived from the intermediate mesoderm and develop in a well-defined temporal and...
The first step in kidney development is the formation of the pronephros which is derived from mesoderm. Xenopus is an appropriate model to study this process since the pronephros can be efficiently induced in animal cap explants by treatment with activin and retinoic acid (RA). Using this in vitro system, we isolated a Xenopus homologue of SMP-30 (Senescence marker protein-30), which is a Ca(2+...
We isolated and characterized the Xenopus translocon-associated protein XTRAP-γ, one of four subunits of the translocon-associated protein complex. TRAP has been proposed to aid the translocation of nascent polypeptides into the lumen of the endoplasmic reticulum, but this has not been demonstrated until now. XTRAP-γ was specifically expressed in the pronephros tubules of Xenopus laevis from st...
The Iroquois (Irx) genes encode evolutionary conserved homeoproteins. We report that Xenopus genes Irx1 and Irx3 are expressed and required during different stages of Xenopus pronephros development. They are initially expressed during mid-neurulation in domains extending over most of the prospective pronephric territory. Expression onset takes place after kidney anlage specification, but before...
In Xenopus, the pronephros is the functional larval kidney and consists of two identifiable components; the glomus, the pronephric tubules, which can be divided into four separate segments, based on marker gene expression. The simplicity of this organ, coupled with the fact that it displays the same basic organization and function as more complex mesonephros and metanephros, makes this an attra...
Following partial nephrectomy in juvenile metamorphosed Xenopus laevis the mitotic activity in the regenerating kidney reached its maximum on the 6th day and returned to its normal level by the 16th day. The mitotic activity was measured in the pronephros and epidermis of prefeeding Xenopus larvae (stage 38) at different intervals after their implantation into the lymph sacs of partially nephre...
The aim of this study was to detect the correlation between the change in the ambient temperature and adaptation of the pronephros – the main haematopoietic organ in fish, which so far has not been subject of research. Compared with other teleosts and their number of blood cells in peripheral blood, tench (Tinca tinca L. 1758) showed the corresponding trend of changes in number of pronephros ha...
Mutations of inversin cause type II nephronophthisis, an infantile autosomal recessive disease characterized by cystic kidney disease and developmental defects. Inversin regulates Wnt signaling and is required for convergent extension movements during early embryogenesis. We now show that Inversin is essential for Xenopus pronephros formation, involving two distinct and opposing forms of cell m...
Vertebrate kidney organogenesis is characterised by the successive formation of the pronephros, the mesonephros and the metanephros. The pronephros is the first to form and is the functional embryonic kidney of lower vertebrates; although it is vestigial in higher vertebrates, it is a necessary precursor for the other kidney types. The Xenopus pronephros is a simple paired organ; each nephron c...
Following partial nephrectomy in juvenile metamorphosed Xenopus laevis the mitotic activity in the regenerating kidney reached its maximum on the 6th day and returned to its normal level by the 16th day. The mitotic activity was measured in the pronephros and epidermis of prefeeding Xenopus larvae (stage 38) at different intervals after their implantation into the lymph sacs of partially nephre...
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