Several proline derivatives such as L-azetidine-2-carboxylic acid, cis-4-hydroxy-L-proline, and 3,4-dehydro-DL-proline prevent procollagen from folding into a stable triple-helical conformation, thereby reducing excessive deposition of collagen in fibrotic processes and the growth of tumors. This study was performed to investigate whether the recently discovered human proton-coupled amino acid ...

Stress-induced proline accumulation in plants is thought to result primarily from enhanced proline biosynthesis and decreased proline degradation. To identify regulatory components involved in proline transport, we screened for Arabidopsis thaliana T-DNA mutants with enhanced tolerance to toxic levels of exogenous proline (45 mM). We isolated the proline resistant 1-1 (pre1-1) mutant and map-ba...

Abbreviations. AGP, arabinogalactan protein; EGFP, enhanced green fluorescent protein; GPI, glycosylphosphatidylinositol; GAGP, gum arabic glycoprotein; GT, glycosyltransferase; HRGP, hydroxyproline rich-glycoprotein; LeAGP1, arabinogalactan protein 1 from tomato; Lys, lysine rich domain; P4H, prolyl-4-hydroxylase; (SP), serine-proline repeat; (VP), valine-proline repeats; (TP), threonine-proli...

Excised bean (Phaseolus vulgaris) leaves were used to measure changes in proline content and proline metabolism during rehydration in the dark after the leaves had been incubated in the dark 24 hours in a wilted condition.The increase in nonprotein proline which occurs in wilted leaves stopped immediately upon rehydration, and thereafter levels of proline declined. The rate of decline and the f...

Proline has long been known to accumulate in plants experiencing water limitation and this has driven studies of proline as a beneficial solute allowing plants to increase cellular osmolarity during water limitation. Proline metabolism also has roles in redox buffering and energy transfer and is involved in plant pathogen interaction and programmed cell death. Some of these unique roles of prol...

abstract this experiment was carried out to determine the effects of proline and ascorbic acid on chilling injury, electrolyte leakage, lipid peroxidation, peroxide hydrogen and antioxidant enzymes activity of thompson grape (vitis vinifera l.) fruit. grape fruits were treated by 0 (control), 250 and 500 µm proline and 0 (control), 2 and 4% ascorbic acid and their combinations, then stored at 1...

abstract   background: the polymorphic variants at codon 72 of the p53 gene, encoding either proline or arginine at residue 72, produce marked change in the structure of p53. from the evidence that the dnamismatch repair system and p53 interact to maintain genomic integrity, we hypothesized that the codon 72 variation may influence the prevalence of microsatellite instability a feature of malig...

Proline accumulation in Escherichia coli is mediated by three proline porters. Proline catabolism is effected by proline porter I (PPI) and proline/delta 1-pyrroline carboxylate dehydrogenase. Proline did not accumulate cytoplasmically when E. coli was subjected to osmotic stress in minimal salts medium. Although PPI is induced when proline is provided as carbon or nitrogen source, its activity...

Staphylococcus aureus is a common cause of disease in humans, particularly in hospitalized patients. This species needs to import several amino acids to survive, including proline. Previously, it was shown that an insertion mutation in the high-affinity proline uptake gene putP in strain RN6390 affected proline uptake by the bacteria as well as reducing their ability to survive in vivo. To furt...