background: leishmania is a significant health problem in many parts of the world. tumor necrosis factor (tnf) plays an essential role in leishmania major infections. objective: to study the pro-inflammatory cytokines and antioxidants in four groups of cutaneous leishmaniasis patients. methods: 39 patients were divided into four groups of: 1) active (acute phase of treatment); 2) non-healing (r...

The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymic S1P homeostasis that ultimately promotes the premature exit of immature CD4(-)CD8(-) T cells ex...

Background: Leishmania is a significant health problem in many parts of the world. Tumor necrosis factor (TNF) plays an essential role in Leishmania major infections. Objective: To study the pro-inflammatory cytokines and antioxidants in four groups of cutaneous leishmaniasis patients. Methods: 39 patients were divided into four groups of: 1) active (acute phase of treatment); 2) non-healing (r...

Purpose and methodology: This study investigated the effect of plain kefir on glycemic, antioxidants, immune response and pancreatic β cell regeneration of hyperglycemia Wistar Rats induced by Streptozotocin. Findings: Kefir supplementation 3.6 cc / day affect significantly on blood glucose, antioxidants, lipid peroxidation, and pancreatic β-cells. Statistical analysis showed reduce of glucose ...

The underlying mechanisms of skin inflammation in atopic dermatitis (AD) are not completely understood but inflammatory cell activation and dysregulated cytokine production appear to play a critical role in pathogenesis of AD. Inducible nitric oxide synthase (iNOS) is expressed by dermal endothelial cells and perivascular inflammatory cells in the atopic skin lesion, suggesting the involement o...

background: mesenchymal stem cells (msc) have ability to regulate immune response via proinflamatory cytokines. in this study we aimed to investigate the effect of different mechanism for t cell activation and adjacency on immunoregulatory properties of msc. methods: bone marrow mscs were purchased and t cells were obtained from whole blood sample. t cells were activated by two different mechan...

Vitiligo is a pigmentation disorder in which inflammatory mediators such as cytokines have a pivotal role in disease's pathogenesis. Interleukin 17 (IL-17A) is a proinflammatory cytokine which is involved in the induction of several proinflamatory mediators such as cyclooxygenase 2 (COX2). The aim of this study was to investigate the gene expression of IL-17 and COX2 in peripheral blood leukocy...

BACKGROUND The variations in proinflamatory cytokine levels have been associated with schizophrenia (SCH), duration of illness, psychopathology and treatment. The aim of the study was to investigate serum levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in schizophrenic patients during exacerbation and remission, and its association with course of illness and therapy. SU...

IL-36γ is a proinflamatory cytokine which belongs to the IL-1 family of cytokines. It is expressed in the skin and by epithelial cells (ECs) lining lung and gut tissue. We used human 3-D organotypic cells, that recapitulate either in vivo human vaginal or cervical tissue, to explore the possible role of IL-36γ in host defense against pathogens in the human female reproductive tract (FRT). EC we...