involvement of genetic alterations in breast cancer, one of the most common types of female malignancie, has been well documented . among the possible alterations, mutations in several genes including p53 as an important prognostic factor, have been extensively studied. mutated p5 protein has longer half-life than the wild type protein that is detectable by immunohistochemistry (ihc). our study...

introduction: the majority of leukemia patients are acute leukemia patients, so that about 70.8% lymphoblastic leukemia were acute lymphoblastic leukemia (all) patients and 66.4 % of myeloid leukemia patients were acute myeloid leukemia (aml) in tehran metropolitan. during the last two decades, intensification of therapy by the use of high-dose cytarabine allogeneic stem cell transplantation in...

background: the breast cancer is the most prevalent cancer among women, on the other hand absence of myoepithelial cells play a pivotal role in pathogenesis of this cancer. thus we aimed to investigate the possible abilities of the molecular assay technique to find a relationship between mammary serine protease inhibitor (maspin) gene expression possibly secreted by myoepithelial cells, grade o...

background: ischemic heart disease and acute myocardial infarction is one of the most dramatic manifestations in one of the most investigated fields in the past few decades. in this study, the prognostic value of white blood cells count in patients with myocardial infarction (mi) was investigated in a six months follow-up. methods: in this cohort study, 106 patients with mi were investigated. w...

cervical cancer is the third most common cancer among women in malaysia. the objective of this study was to estimate the effect of explanatory variables on survival time of cervical cancer patients receiving treatment at a hospital in malaysia.in this retrospective record review study, cervical cancer data obtained from hospital universitisains malaysia (husm) was analysed. the data comprises o...

background: primary gastric lymphoma (pgl) is an uncommon malignancy with various histological subtypes and treatment outcomes. the aim of this study was to investigate the potential prognostic factors and clinicopathological characteristics of iranian patients with pgl. methods: the clinicopathological characteristics of 60 patients with pgl were retrospectively reviewed from 2001 to 2012. the...

background: the goal of antivenom administration for snake-bitten patients is to achieve therapeutic response (initial control), which means reversal of the venom-induced effects through neutralizing the venom. the aim of this study was to identify snakebite prognostic factors of weak therapeutic response prior to antivenom administration. methods: this was a retrospective study of patients wit...

objective(s): breast cancer is the most common type of cancer among women worldwide. this study investigated the expression and clinical significance of activating transcription factor 3 (atf3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   materials and methods : atf3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent norm...

conclusions according to this study, igvh3 mutation was found to be prevalent (although a correlation was found to exist between the patients’ survival and igvh mutation, it was not statistically significant). we can conclude that clinical methods are still valuable to predict the prognosis of patients with cll. given the high cost and need for specialized laboratory, determining the cost and v...

human epidermal growth factor receptor-2 (her-2) as a new prognostic and predictive factor has been believed as an essential measurement in breast carcinoma. about 280 articles were reviewed and 115 were referred in this review article on her-2. her-2 is an oncoprotein epidermal growth factor receptor produced by a so-called cell surface oncogene. overexpression results in aggressive behavior, ...