This paper investigates a multi-period rectilinear distance 1-center location problem considering a line-shaped barrier, in which the starting point of the barrier follows the uniform distribution function. In addition, the existing points are sensitive to demands and locations. The purpose of the presented model is to minimize the maximum barrier distance from the new facility to the existing ...

This paper considers the Tchebychev distance for a facility location problem with a probabilistic line barrier in the plane. In particular, we develop a mixed-integer nonlinear programming (MINLP) model for this problem that minimizes the total Tchebychev distance between a new facility and the existing facilities. A numerical example is solved to show the validity of the developed model. Becau...

This paper presents a single facility location problem in the presence of a probabilistic line barrier. The aim of this problem is to minimize bi-objectives, namely the total expected barrier distance and the maximum expected barrier distance from each demand point to the new facility point. Based on our best knowledge, there is no such a mathematical model to present this problem in the litera...

membrane permeability and p-glycoprotein (p-gp) efflux system are regulating factors in the drug brain penetration. recently, some drug delivery systems have been developed to overcome these limitations. in this study, metoclopramid has been encapsulated in plga nanoparticles using the emulsification/solvent evaporation technique for in vitro evaluation of the effect of plga nanoparticles on bb...

This paper investigates a multi-period rectilinear distance 1-center location problem considering a lineshaped barrier, in which the starting point of the barrier follows the uniform distribution function. In addition, the existing points are sensitive to demands and locations. The purpose of the presented model is to minimize the maximum barrier distance from the new facility to the existing f...