Several species of Prangos are traditionally used as emollient, carminative, tonic, anti-flatulent, anthelmintic and anti-thrombotic agents. Osthole, a coumarin isolated from Prangos, are believed to be responsible for some of its effects. In this research, relaxant effects of Prangos ferulacea extract and osthole on rat uterus contraction induced by KCl, acetylcholine (ACh), oxytocin and elect...

objectives: diabetes mellitusmanifests itself in a wide variety of complications and the symptoms of this disease are multifactorial. previousstudies proved that this disease is directly related to hyperglycemia and hyperlipidemia. the aim of this study was to investigate the hypoglycemic and hypolipidemic effects of hydroalcoholic extract of prangos frulacea (l.)lindlin alloxan-induced diabeti...

Background The present study was conducted on the effect of prangos ferulacea vaginal cream on accelerating the recovery of bacterial vaginosis. Methods This randomized controlled clinical trial was conducted on 100 non-pregnant women referring to health centers affiliated to Lorestan University of Medical Sciences in 2016 with the diagnosis of bacterial vaginosis based on the patient's compl...

Prangos ferulacea (L). Lindl. Erzurum ili ve çevrelerinde halk arasında tıbbi gıda amaçlı olarak kullanılan bir bitkidir. Özellikle şehrin kuzey taraflarında her yılın Mayıs ayında toplanan P. (Yöresel adı Çaşır, Çakşır) yaprakları salamura yapılarak tüm yıl boyunca tüketilmektedir. Bu çalışmada araziden bitkinin kurutulup 6 farklı çözücü ile (su, metanol, %70 meoh, hekzan, kloroform, aseton) e...

Natural products are excellent resources for finding lead structures for the development of chemotherapeutic agents. Coumarins are a class of natural compounds found in a variety of plants. In this study, we evaluated the cytotoxic potential of coumarins isolated from Prangos ferulacea (L.) Lindl. in PC3, SKNMC, and H1299 (p53 null) human carcinoma cell lines. Osthole proved to be an outstandin...

Prangos ferulacea is a plant found in the Mediterranean and Middle-east regions used as carminative, anti-flatulent, emollient and antibacterial herb. It is believed that the coumarins are responsible for some of known effects of Prangos. In this research the relaxant effects of P. ferulacea coumrin rich extract as well as osthole as its main prenylated coumarins were investigated on rat ileum ...