This paper describes an in vitro study of three potential acetylcholinesterase (AChE; EC 3.1.1.7) reactivators derived from a monoquaternary reactivator pralidoxime. Compounds used were pyridinium-2-aldoxime-4-carbamoyl-N-methyl iodide (TO231), pyridinium-2-aldoxime-4-ethoxycarbonyl-N-methyl iodide (TO237), and pyridinium-2-aldoxime-5-ethoxycarbonyl-N-methyl iodide (TO238). Pralidoxime and obid...

organophosphate (op) poisoning is one of the most common causes of poisoning in developing countries especially in southeastern asia. poisoning with phosphorus-containing organic chemicals or op compounds can be managed with antidotes like oximes which are potential reactivators of acetylcholinesterase (ache). the efficacy of oxime therapy in op poisoned patients mainly depends upon various fac...

background: the effective therapeutic dose of pralidoxime methylsulphate for organophosphate (op) poisoning is necessary to be clarified. this study was designed to comparatively assess the blood level of pralidoxime (bpl) and clinical outcomes in op poisoned patients treated with intermittent dosing and patients treated with continuous infusion. methods: this was a prospective, open labelled, ...

BACKGROUND Poisoning with organophosphorus (OP) insecticides is a major global public health problem, causing an estimated 200,000 deaths each year. Although the World Health Organization recommends use of pralidoxime, this antidote's effectiveness remains unclear. We aimed to determine whether the addition of pralidoxime chloride to atropine and supportive care offers benefit. METHODS AND FI...

1 College of Environmental Science, Peking University, Beijing, 100871, People’s Republic of China 2 Ministry of Education, Key Laboratory for Three Gorges Reservoir Area Ecological Environment, Chongqing University, Chongqing, 400045, People’s Republic of China 3 The State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Science, Chinese Academy of Scien...

The synthesis of α-aminosilanes by a highly enantio- and regioselective copper-catalyzed hydroamination of vinylsilanes is reported. The system employs Cu-DTBM-SEGPHOS as the catalyst, diethoxymethylsilane as the stoichiometric reductant, and O-benzoylhydroxylamines as the electrophilic nitrogen source. This hydroamination reaction is compatible with differentially substituted vinylsilanes, thu...

organophosphate (op) compounds are frequently used agorchemicals for deliberate self-harm in some parts of the world resulting in high mortality and morbidity. pralidoxime (2pam) is the most widely used and trialed oxime for treatment of op poisoning. there have been variations over the results of trials using 2pam for op poisoning. 2pam therapy has led to favorable outcomes in some studies, wh...

background: for effective treatment of organophosphate (op) poisoning, development of a standardized protocol with flexible dose regimen for atropine and pralidoxime is an essential step. in this study, we aimed to assess the protocol devised in our setting; bach mai hospital poison treatment center, for treatment of op poisoning that included a higher dose regimen of pralidoxime (2pam). method...

background: the role and proper dose of pralidoxime in the treatment of organophosphorus (op) compounds poisoning is an unresolved issue .this study was designed to compare the regimen recommended by the world health organization (who) with the commonly used standard regimen of pralidoxime. methods: this was a randomized open labeled prospective study on op poisoned patients admitted to jss hos...

A new family of Tetraazamacrocyclic Ru(II) complexes [RuCl2(L)] (where L = N4 donor macrocyclic ligands) have been synthesized by the reactions of [RuCl2(DMSO)4] with some of macrocyclic Schiff base ligands containing N4 donor groups. The complexes were characterized by elemental analysis, IR, H, C NMR, mass, electronic, molar conductance and magnetic susceptibility measurements. An octahedral ...