PURPOSE To determine whether the use of mupirocin ointment for preoperative eradication of nasal bacterial carriage was effective in reducing conjunctival bacterial flora. METHODS Prospective, double-arm, blinded clinical trial of 37 eyes of 37 patients undergoing intraocular surgery (cataract extraction or pars plana vitrectomy) randomized to either control or mupirocin treatment groups. Tre...

The aim of this study was to prevent eschar formation in thermally injured patients during the use of povidoneiodine ointment by modifying therapeutic protocols depending on normal events in healing process. Sixty thermally injured patients of different age groups, sex, and occupation with different burn sizes were involved in the study, allocated to two groups. Group A was made up of 17 patien...

BACKGROUND Treatment of Staphylococcus aureus colonization before surgery reduces risk of surgical site infection (SSI). The regimen of nasal mupirocin ointment and topical chlorhexidine gluconate is effective, but cost and patient compliance may be a barrier. Nasal povidone-iodine solution may provide an alternative to mupirocin. METHODS We conducted an investigator-initiated, open-label, ra...

INTRODUCTION Infection is a major threat to wound healing and a leading cause of graft loss in patients undergoing meshed skin grafts (MSGs). Therefore, topical antisepsis is important in the overall treatment scheme. METHODS An exploratory satellite group of 14 patients with infected MSGs were enrolled as part of a prospective, randomized, controlled, parallel-group, open-label, pilot Phase ...

Topical iodine forms are used for infected and necrotic pressure ulcers. Despite antimicrobial advantages several potential disadvantages were observed with controversial results. To clarify the controversy, the reactivity of povidone-iodine (PI) sugar ointment and cadexomer-iodine (CI) ointment toward biological components was investigated. L-Tyrosine as a component of proteins and egg lecithi...

Albeit uncommon occurrence, irritant contact dermatitis induced by povidone iodine can be an unfortunate adverse reaction complicating its use as an antiseptic. We hereby present the case report of a patient who suffered such a reaction as a result of exposure to povidone iodine, employed as an antiseptic during spinal anesthesia. On conservative management with soframycin ointment, the lesions...

objective: martynia annua l. (m. annua), (martyniaccae) has been traditionally used in the treatment of epilepsy, sore throat and inflammatory disorders. the leaf paste is used topically on tuberculosis of the lymphatic glands and wounds of domestic animals. tephrosia purpurea (t. purpurea), (fabaceae) has been used traditionally as a remedy for asthma, gonorrhea, rheumatism and ulcers. this st...

neonatal conjunctivitis (ophthalmia neona-tarum) continues to involve many neonates in areas with no eye prophylaxis. povidone iodine solution is an effective antimicrobial agent with broad antibacterial and antiviral activity and it is less expensive and less toxic than the other agents. it seems to be a good alternative for routine eye prophylaxis, especially in developing countries. in a pro...

Present study was aimed to evaluate the wound healing activity of aqueous extract of leaves and roots of Coleus aromaticus using excisional wound model in albino rats. The aqueous extracts were prepared using maceration method and were applied as 5% and 10% ointment. The wound healing activity of these extracts was compared with a standard drug povidone-iodine ointment. The healing tissue was a...

Iodine preparations for external use are recommended for treating pressure ulcers with manifestations of infection and necrosis. These ulcers abundantly produce wound exudates, which could be absorbed by water-soluble base. In this study we aimed to improve the previously reported methodologies for water absorption and new methodologies were developed in Franz diffusion cell with 100kDa molecul...