nitration of potassium sulphamate was carried out using a mixture of sulphuric and nitric acid at -30 °c. the reaction time was optimized at the mole ratio of sulphuric to nitric acid of (1:3.5). the difference in product yield by changing the potassium to ammonium sulphamate was studied throughly. it was found that both the yield and purity of the product is better starting with potassium sulp...

Nitration of potassium sulphamate was carried out using a mixture of sulphuric and nitric acid at -30 °C. The reaction time was optimized at the mole ratio of sulphuric to nitric acid of (1:3.5). The difference in product yield by changing the potassium to ammonium sulphamate was studied throughly. It was found that both the yield and purity of the product is better starting with potassium ...

2-Methoxyestradiol-bis-sulphamate is a bis-sulphamoylated derivative of the naturally occurring 17-beta-estradiol metabolite namely 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate is regarded as a potential anticancer drug with increased antiproliferative activity when compared to 2-methoxyestradiol. The aim of this pilot in vitro study was to determine the influence of 2-methoxyestradiol...

Topiramate is an oral sulphamate medication primarily used for seizure, migraine and neuropathic pain. It has been associated with secondary angle closure, which can mimic acute angle closure glaucoma. Suspicion for medication induced angle closure glaucoma should be higher whenever angle closure presents bilaterally. We present two cases of bilateral angle closure glaucoma secondary to topiram...

5. The rate of synthesis of 2-naphthyl sulphamate by rat-liver preparations is increased by about 400% by 17-oxo steroids in concentrations of approximately 10-5M. 6. The rate ofsynthesis ofsulphamate byguineapig preparations is not increased by 17-oxo steroids. 7. It is suggested that the mechanism of this activation involves the formation of steroid 17-enol sulphates and that these enol sulph...

The fructose-based sugar sulphamate RWJ-37497, a potent analogue of the widely used anti-epileptic drug topiramate, possesses anti-convulsant and carbonic anhydrase-inhibitory activities. We have studied the binding interactions of RWJ-37497 in the active site of human carbonic anhydrase II by X-ray crystallography. The atomic positions of the enzyme inhibitor complex were refined at a resoluti...

In the search for new and improved anticancer therapies, researchers have identified several potentially useful compounds. One of these agents is 2-methoxyestradiol-bis-sulphamate (2ME-BM), a sulphamoylated derivative of 2-methoxyestradiol. The objective of this study was to evaluate 2ME-BM's in vitro efficacy as antiproliferative agent in the MCF-7 breast adenocarcinoma cell line. Light- and f...