The aim of present work was to optimize the effect of Ethyl Cellulose (EC) and Polyvinyl Pyrrolidone (PVP) concentration in extended release solid dispersion of Glibenclamide using combination of hydrophilic and hydrophobic polymers such as Polyvinyl Pyrrolidone and Ethyl cellulose. The advantage of solid dispersion technique provides a unique approach to particle size reduction and increased r...

The ability of β-cyclodextrin, hydroxypropyl-β-cyclodextrin, polyvinyl pyrrolidone and urea to influence the percutaneous absorption of meloxicam through isolated rat skin was evaluated. Carrier complex were prepared by kneading method in 1:1 and 1:2 in molar ratios for β-cyclodextrin and hydroxypropyl-β-cyclodextrin and in 1:1, 1:3 and 1:5 in weight ratios for polyvinyl pyrrolidone and urea. T...

bovine oocytes matured in culture were denuded from cumulus cells with hyaluronidase and by repeat pipetting trough a fine pasture pipete and were inseminated with frozen-thawed spermatozoa in a protein-free bo medium containing 5m m-caffeine, l0 mg heparin/ml and with or without polyvinyl pyrrolidone (pvp) and different concentrations of hyaluronic acid. when oocytes were inseminated in the ab...

Purpose: Recurrent aphthous stomatitis (RAS) is the most common painful ulcerative disease of oral mucosa happening in ~20% of people. Aimed to develop Myrtus communis L. (Myrtle) containing oral patches, we applied box-behnken design to evaluate the effect of polymers such as Polyvinyl pyrrolidone (PVP), Gelatin, Methylcellulose (MC) and Pectin. Methods: The patches properties such as tensile ...

losartan potassium is a well known orally active non-peptide angiotensin ii receptor antagonist. losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin ii by selectively blocking the binding of angiotensin ii to at1 receptors. the drug is reported to promote the decrease in ventricular hypertrophy, salt and water excreti...

Early reformation of the anterior chamber after intraocular surgery is of paramount importance, its absence or delay leading to peripheral anterior synechiae and aphakic glaucoma (Troncoso, 1933; Kronfeld and Grossman, 1941; McLean, I94I; Meyer and Sternberg, 1950). Selinger (1937) injected air after cataract operations to restore the normal curvature of the cornea. He concluded that air preven...

Thermally stimulated depolarization current (TSDC) characteristics of Polyvinyl Pyrrolidone (PVP) electrets are studies in the temperature range 30 to 210 C as functions of the polarizing field (5 to 100kV/cm) and polarizing temperature (40 to 80C). The TSDC spectra comprise two maxima, namely, β and α with their respective locations around 90 C and 172.5 C. These are attributed to dipoleorient...

Polyvinyl pyrrolidone has been widely used in recent years as a plasma expander, and a few side-effects have been reported, mostly reactions considered due to allergic or similar mechanisms. A few histological changes have been noted in man such as the liver lesions reported by Gall, Altemeier, Schiff, Hamilton, Braunstein, Giuseffi, and Freiman (1953) and the work of Vickery (1956), but in gen...

Purpose: To prepare and evaluate bioadhesive buccal films of diltiazem hydrochloride (a L-type calcium channel blocker) for overcoming the limitations of frequent dosing, low bioavailability and gastrointestinal discomfort of oral delivery. Methods: Buccal films were prepared by solvent casting technique using sodium carboxymethylcellulose, polyvinyl pyrrolidone K-30 and polyvinyl alcohol. The ...