tumor necrosis factor alpha-inducible protein 3 (tnfaip3) gene polymorphisms have been reported to be associated with the susceptibility to several immune-related diseases. here we investigated the effect of tnfaip3 gene polymorphisms on the risk of allergic rhinitis (ar) in a chinese han population. the case-control study included 540 ar patients and 524 healthy controls. genotyping for tnfaip...

conclusions the current meta-analysis showed an association between frequency of gg genotype of pnpla3 and the risk of development of chc in various populations throughout the world. results five hospital-based case-control studies were included in the final analysis. the overall frequency of pnpla3 gene polymorphisms was 20.4% (205/1005) in chc and 10.23% (53/518) in controls. the summary odds...

background: approximately 10-14% of the clinically acknowledged pregnancies end with spontaneous abortion at caucasian population. possible immunologic causes of recurrent miscarriages have been extensively researched. the change in the cytokines balance synthesis in favor of those synthesized by th2 cells with an increase of interleukin 6 (il6) and interleukin10 (il10) secretion is considered ...

background: we aimed to identify the role of sirt 6 gene polymorphism rs350846 in human longevity. methods: sirt 6 c/g genotypes were determined using taqman snp genotyping assays in 169 long-lived inhabitants (lg group aged 90-110 yr), 158 healthy internal controls (internal control group; aged 26-82 yr) and 176 healthy external controls (external control group; aged 20-82 yr) without a family...

glutathione s-transferases (gsts) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. the human gsts are divided into four classes: alpha, mu, pi and theta. previous studies indicated that the absence of the glutathione s-transferase m1 (gstm1) protein correlated with an increased risk of developing some types of cancers. association between spe...

background multiple sclerosis (ms) is an autoimmune disease that affects the central nervous system (cns). ms is one of the most common cause of neurological impairment at a young age with a complex etiology. the forkhead/winged helix (foxp3) gene encodes a transcription factor that plays an important role in the working and progress of regulatory t cells. loss of the foxp3 function impairs the...

introduction: endometriosis is a prevalent gynecological disorder among women which is diagnosed by the growth of endometrial tissue outside of uterus and is mainly accompanied by severe pelvic pain and infertility. p53 also known as cellular tumor antigen p53 inside codons 11, 72 and 248 are contained with single nucleotide changes in which tends to be nearly rampant.this will probably be incr...

conclusions our meta-analysis, while not ruling out possible publication bias, showed no association between gene polymorphisms of apoc3 and the risk of nafld development in different populations in the world. evidence acquisition we performed a meta-analysis of all relevant studies published in the literature. a total of 115 clinical trials or reports were identified, but only seven trials met...

background: the aim of this study was to examine the interaction of dietary food groups and genetic variants of apoa1/apoc3, relative to metabolic syndrome (mets) risk in adults. methods: in this matched nested case-control study, 414 mets subjects and 414 controls were selected from among participants of tehran lipid and glucose study. dietary intake was assessed with the use of a valid and re...

background: the pathogenesis of many diseases is correlated to irregularity in vascular endothelial growth factor (vegf) expression. results from several association studies show that variation in the level of vegf expression is related to polymorphic sequences within the vegf gene. additionally, there are many studies showing that some gene polymorphisms significantly influence the pharmacokin...