نتایج جستجو برای: Polymorphic Trinucleotide
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Background s:648:"The infertility has recently been estimated to affect approximately 9% of couples worldwide. Androgens and a functional androgen receptor (AR) are essential for normal development of the male gender, and for maintenance of spermatogenesis throughout the life. Two polymorphic trinucleotide repeats, CAG and GGN, encoding for the amino acids glutamine and glycine, respectively ar...
A total of 2,970 EST-SSRs (2.38%) were identified by transcriptome sequencing of clam Meretrix meretrix (751,970 reads, ~310.82 Mbp), using 454 Genome Sequencer FLX next-generation sequencing platform. Dinucleotide SSR was the dominant repeat type (40.2%), followed by trinucleotide (37.8%), tetranuleotide (12.0%) and pentanucleotide (2.0%) SSR. The dominant repeat motif was AT (71.3%) in the di...
UNLABELLED PREMISE OF THE STUDY Genic microsatellites or simple sequence repeat (genic-SSR) markers were developed in boxwood (Buxus taxa) for genetic diversity analysis, identification of taxa, and to facilitate breeding. • METHODS AND RESULTS cDNA libraries were developed from mRNA extracted from leaves of Buxus sempervirens 'Vardar Valley' and sequenced using the Illumina MiSeq system. ...
The herpes simplex virus type 1 (HSV-1) genome is a linear double-stranded DNA of 152 kpb. It is divided into long and short regions of unique sequences termed U(L) and U(S), respectively, and these are flanked by regions of inverted internal and terminal repeats. Microsatellites are short tandem repeats of 1- to 6-nucleotide motifs; they are often highly variable and polymorphic within the gen...
Tandem repeats, that is simple sequence repeats, occur commonly in the human genome, and they have long been used as markers in linkage studies. In this decade, it has also been found that tandem repeats underlie an entirely new class of human mutations. The expansion of a group of trinucleotide repeats is now known to cause several inherited diseases, all of which are neurological disorders. T...
Objective: To report a successful case of preimplantation genetic diagnosis (PGD) for Huntington’s disease using whole genome amplification Design: Case report Setting: University assisted reproduction unit Patient(s): A couple with family history of Huntington’s disease; the husband was carrying the expanded allele of the IT15 gene, while the wife had the normal allele. Intervention(s): PGD wi...
OBJECTIVE To report a successful case of preimplantation genetic diagnosis (PGD) for Huntington disease using whole genome amplification. DESIGN Case report. SETTING University assisted reproduction unit. PATIENT(S) A couple with family history of Huntington disease: The husband was carrying the expanded allele of the IT15 gene, and the wife had the normal allele. INTERVENTION(S) Preimp...
The two most consistent features of the diseases caused by trinucleotide repeat expansion-neuropsychiatric symptoms and the phenomenon of genetic anticipation-may be present in forms of dementia, hereditary ataxia, Parkinsonism, bipolar affective disorder, schizophrenia and autism. To identify candidate genes for these disorders, we have screened human brain cDNA libraries for the presence of g...
Rye (Secale cereale L.) is important food crop in Russia. The study of the genetic diversity crops carried out using molecular markers. To identify effective primers, ISSR (Inter Simple Sequence Repeats), a method for determining DNA polymorphism, was used.The selection primers according to largest number polymorphic fragments, their clear amplification and reproducibility repeated PCR. Of 22 a...
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