CMS, core-multishell; NR, Nile red; MTX, methotrexate; mPEG, methoxypoly(ethylene glycol); PG, polyglycerol; dPG, dendritic polyglycerol; PEG, poly(ethylene glycol); CMS-mPEG, coremultishell nanocarrier with a mPEG outer shell; EPR, enhanced permeation and retention; PG[G1], polyglycerol dendron of generation 1; PG[G2], polyglycerol dendron of generation 2; CMS-G1, core-multishell nanocarrier w...

Herein we report the synthesis of water-soluble polyglycerol-dendronized perylenediimides with a single reactive group that undergoes high-yielding click reactions. Single-molecule studies and target-specific biolabeling are reported, including the highly specific labeling of proteins on the surface of living bacterial and mammalian cells.

The synthesis and photophysical properties of water-soluble, fluorescent polyglycerol-dendronized perylenediimides 1-4 are reported. The polyglycerol dendrons, which are known to be highly biocompatible, are found to confer high water-solubility on the perylenediimide in aqueous media while retaining its excellent fluorescent properties. Furthermore, intramolecular cross-linking of the polyglyc...

Doxorubicin-loaded nanogels with multiresponsive properties are prepared using hyperbranched polyglycerol as a biocompatible scaffold. The nanogels are synthesized in a single step combining free-radical polymerization and a mild nanoprecipitation technique. The nanogels respond to different biological stimuli such as low pH and reductive environments, resulting in a more efficient cell prolife...

The fast and simple method for total chlorine determination in polyglycerols using low resolution inductively coupled plasma mass spectrometry (ICP-MS) without the need for additional equipment and time-consuming sample decomposition was evaluated. Linear calibration curve for 35Cl isotope in the concentration range 20-800 µg/L was observed. Limits of detection and quantification equaled to 15 ...

AIMS The goal of the experiment was to verify bioavailability of immunosuppressive drug cyclosporine after oral administration, to determine, in particular, effect of triglycerides and polyglycerol esters on bioavailability of this lipophilic, poorly soluble drug. METHODS 1) Absorption of cyclosporine A from soya oil and polyglycerol-3-oleate was tested after intra-duodenal application to rat...

A polyglycerol dendrimer (PGD) of generation 2, which consists of only glycerol units, constructed nanospace capable of uptake of a fluorescent molecule with a 1:1 stoichiometry. On the other hand, a PGD of generation 1 trapped the molecule at the outer part.

Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we...

A convenient methodology for the synthesis of photolabile crosslinked hyperbranched polyglycerol nanocapsules is presented. These nanocarriers selectively and efficiently bind ionic guest molecules. The stability of the host-guest complexes formed depends on the counterion of the guest molecules. Moreover, the control over guest binding can be achieved by modification of the polymer building bl...