O ur laboratory has developed a number of novel synthetic scaffold materials based on fumaric acid for an assortment of tissue engineering applications. These biodegradable materials include poly(propylene fumarate) (PPF), poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)), and oligo(poly(ethylene glycol) fumarate) (OPF), each of which can be applied as an injectable liquid and crosslink...

poly (propylene fumarate) (ppf), a linear unsaturated polyester consisting of alternating propylene glycol and fumaric acid units, can be cured in vivo to fill the skeletal defects with minimal surgical intervention. many different methods have been reported for synthesizing ppf, but none of them gives a clear method. the present paper introduces two new methods in ppf synthesis: modified reflu...

Polymer dynamics is the essence of polymer physics. Understanding polymers from the perspective of polymer dynamics is crucial to rationally design and fabricate novel polymeric systems. Poly(propylene fumarate) (PPF) and poly(propylene fumarate)-copolycaprolactone (PPF-co-PCL) (Fig. 1) are two unsaturated linear polyesters that can be crosslinked through its fumarate double bonds. By varying t...

Hydrogels are deployed widely in all areas of regenerative medicine, including bioprinting. The transport and mechanical properties exhibited by hydrogel assemblies controlled their organization hierarchical assembly. This paper points out the role nanoscale size ordering hydrophobic cross-linked domains on degradation three-dimensional (3D) printed amphiphilic hydrogels. A series six poly(prop...

Biodegradable thermogelling copolymer hydrogels have great applicative potential in areas such as sustained drug release, gene delivery and tissue engineering. These injectable materials can be implanted in the human body with minimal surgical intervention. The thermosensitive copolymers have been incorporated with a variety of biocompatible and biodegradable components such as poly(D,L-lactic ...

Biodegradable micelle systems with both extracellular stabilities and specific targeting properties are highly desirable for anti-cancer drug delivery. Here, we report a biodegradable and crosslinkable poly(propylene fumarate)-co-poly(lactide-co-glycolide)-co-poly(ethylene glycol) (PPF-PLGA-PEG) copolymer conjugated with folate (FA) molecules for receptor-mediated delivery of doxorubicin. Micel...

Three-dimensional (3-D) scaffolds with intrinsic porous structures are desirable in various tissue regeneration applications. In this study, a unique method that combines thermally induced phase separation with a photocrosslinking process was developed for the fabrication of 3-D crosslinked polymer scaffolds with densely interconnected porous structures. Biodegradable poly(propylene fumarate)-c...