SYMBLEPHARON is described by all authors discussing conjunctival diseases as adhesion between the palpebral and bulbar conjunctivae. Its aetiology is described as purulent conjunctivitis, diphtheritic conjunctivitis, trachoma, trauma, and so on. These factors do not always cause symblepharon, but may result in a very troublesome condition, apparently not mentioned in the literature, viz. conjun...

Energetic hot spots account for a significant portion of the total binding free energy and correlate with structurally conserved interface residues. Here, we map experimentally determined hot spots and structurally conserved residues to investigate their geometrical organization. Unfilled pockets are pockets that remain unfilled after protein-protein complexation, while complemented pockets are...

The shape of the protein surface dictates what interactions are possible with other macromolecules, but defining discrete pockets or possible interaction sites remains difficult. First, there is the problem of defining the extent of the pocket. Second, one has to characterize the shape of each pocket. Third, one needs to make quantitative comparisons between pockets on different proteins. An el...