it is important to determine whether a candidate molecule is capable of penetrating the plasma-brain barrier indrug discovery and development. the aim of this paper is to establish a predictive model for plasma-brainbarrier penetration using simple descriptors the usefulness of the quantum chemical descriptors, calculated atthe level of the dft and he theories using 6-310* basis set for qsar st...

Medicinal plants have attracted global attention due to their high levels of antioxidant components for prohibiting or improving various diseases including brain and memory disorders. This study was designed to investigate if the antioxidant effect of Sidr (Zizyphusspina-christi) extract can help to improve the scopolamine induced impairment of memory in Wistar rats. Animals were randomly...

Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...

Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...

this study demonstrates the changes in six different pathophysiological parameters such as body weight, body temperature, fecal pellet count, blood-brain barrier (bbb) permeability, plasma corticosterone level and emergence of hemorrhagic peptic ulcer spots due to exposure to high environmental heat in three different age groups of freely moving rats. methods: each age group of rats was sub div...

Background: In the present study, we hypothesized that conditioned medium (CM) derived from mesenchymal stem cells attenuates the brain oxidative stress in sepsis induced by the cecal ligation and puncture (CLP) model. Methods: This study was performed in the Department of Physiology at Tehran University of Medical Sciences from August 2018 to April 2019. Conditioned medium was collected from ...

Hypertonic solutions play an important role in the treatment of tissue edema. Following the induction of experimental vasogenic brain edema by occlusion of the common carotid arteries in eight rabbits, the effect of hypertonic lactated Ringer's solution (subjects), vs. isotonic lactated Ringer's solution (control), was studied on blood pressure, electrolyte (sodium, potassium, and calcium) ...

While fasting has been practiced for centuries, its beneficial effects was unknown until recently. This review tries to analyze the current literature of how fasting and intermittent fasting (IF) could affect clinical pathological parameters, learning, mood and brain plasticity. The effects of different ways of fasting on metabolism and stress were also explored. Animal experiments have elucida...

P-glycoprotein (Pgp) overexpressed in blood brain barrier (BBB) is hypothesized to lower drug concentrations and thus inhibit anticonvulsant effects drug-resistant epilepsy. Pluronic P85 (P85) was proved enhance the delivery of drugs into by inhibition Pgp. To determine whether surfactant [versus Pgp inhibitor tariquidar (TQD)] phenytoin (PHT) rats with chronic mesial temporal lobe epilepsy (MT...