Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of noxious heat and capsaicin. Its channel activity can be modulated by several mechanisms. Here we identify a membrane protein, Pirt, as a regulator of TRPV1. Pirt is expressed in most nociceptive neurons in the dorsal root ganglia (DRG) including TRPV1-positive cells. Pirt null mice show impaired responsiveness to noxious ...

Uterine contraction-induced pain (UCP) represents a common and severe form of visceral pain. Nerve fibers that innervate uterine tissue express the transient receptor potential vanilloid channel 1 (TRPV1), which has been shown to be involved in the perception of UCP. The phosphoinositide-interacting regulator of TRP (Pirt) may act as a regulatory subunit of TRPV1. The intraperitoneal injection ...

Pirt is a membrane protein that is specifically expressed in the peripheral nervous system, where it has been shown to increase the sensitivity of the transient receptor potential vanilloid 1 channel and modulate its role in heat pain. The broad expression of Pirt among dorsal root ganglion neurons suggests it may modulate other transient receptor potentials, such as the menthol and cooling sen...

.......................................................................................................................................... 2 1 Introduction ............................................................................................................................. 5 1.1 History of Domestic Commercial Reactor Development and Licensing ......................... 5 1.1.1 ...

OBJECTIVE To develop a clinical prediction model for poor outcome after intensive care unit (ICU) discharge in a large observational data set and couple this to an acute post-ICU ward-based review tool (PIRT) to identify high-risk patients at the time of ICU discharge and improve their acute ward-based review and outcome. DESIGN Retrospective patient cohort of index ICU admissions between Jun...

Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation. Pir...

Phenomenon identification and ranking tables (PIRTs) were developed by an international group of fuel experts for three postulated accident types that are important in plant safety analysis. Rankings were determined with regard to cladding damage and fuel dispersal for high-burnup fuel rods. Developing PIRTs is a structured way of obtaining expert opinions to help improve computer codes and to ...

BACKGROUND Patients have the potential to provide a rich source of information on both organisational aspects of safety and patient safety incidents. This project aims to develop two patient safety interventions to promote organisational learning about safety - a patient measure of organisational safety (PMOS), and a patient incident reporting tool (PIRT) - to help the NHS prevent patient safet...

It is appropriate that this lecture is being given in Cambridge because Marjory Stephenson spent most of her life here and indeed was born only ten miles away in Bunvell. However, she taught for a while in London at Unix ersity College and King’s College of Household Science. Her connection with the latter College is of particular interest to me because King’s College of Household Science event...

This AUTO demo shows the use of a set of boundary conditions for the localization and continuation of the transcritical bifurcation of a limit cycle in a four-dimensional Marr-Pirt model.