The efficacy, tolerability, and acceptability of topical applications of ketoprofen gel (2.5% w/w), piroxicam gel (0.5% w/w), and diclofenac gel (1% w/w), when administered three times daily for 5 days, in the treatment of acute (within 48 hours) soft-tissue injury, were compared in an open-label, randomized, multicenter, general practice study. Of 1575 patients recruited, 1048 received ketopro...

      Piroxicam is a non-steroidal anti-inflammatory agent which has an extensive use in rheumatic disorders. Since its skin penetration is still a subject for research, the aim of this study was to evaluate the effect of dimethyl sulfoxide on percutaneous penetration of piroxicam gel formulation through skin. In this study, as a model, two types of 0.5% piroxicam new gels, so called red and gr...

piroxicam is a non-steroidal anti-inflammatory agent which has an extensive use in rheumatic disorders. since its skin penetration is still a subject for research, the aim of this study was to evaluate the effect of dimethyl sulfoxide on percutaneous penetration of piroxicam gel formulation through skin. in this study, as a model, two types of 0.5% piroxicam new gels, so called red and green ge...

OBJECTIVE : To evaluate the efficacy and safety of a homeopathic gel vs an NSAID (piroxicam) gel in the treatment of osteoarthritis of the knee. METHOD : One hundred and eighty-four out-patients with radiographically confirmed symptomatic osteoarthritis of the knee were entered into a pragmatic, randomized, double-blind controlled trial and treated with 1 g of gel three times daily for 4 week...

objective: the main purpose of this study was to evaluate the effects of virgin olive oil phonophoresis on female athletes' anterior knee pain (akp). materials and methods: a double blinded randomized clinical trial was conducted. ninety-three female athletes suffering from akp voluntarily participated in this study. patients were randomly assigned into olive oil (n=31), piroxicam (n=31) o...

It is over several decades that ultrasound is used to enhance the transdermal drug delivery (phonphoresis). The mechanism of the enhancement is not fully understood and the ability of ultrasound on the enhancement for some drugs is unclear. The effect of continuous wave 870 KHz ultrasound at intensity of 1 W/cm 2 for 15 minutes on transdermal absorption of piroxicam from solution and gel formu...

Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermatological products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to evaluate the effect of incorporating a few common penetration enhancers (in different concentrations) into a 0.5% w/w piroxicam (model drug) gel formulation, on th...

OBJECTIVES The aim of the study was to prepare a sublingual formulation for piroxicam using a thermosensitive polymer and to evaluate its permeation through porcine sublingual mucosa. METHODS Formulation technique utilized the transition property of poloxamer from solution state at room temperature to gel state at oromucosal temperature (37 °C). The permeation of the drug was evaluated using ...

it is over several decades that ultrasound is used to enhance the transdermal drug delivery (phonphoresis). the mechanism of the enhancement is not fully understood and the ability of ultrasound on the enhancement for some drugs is unclear. the effect of continuous wave 870 khz ultrasound at intensity of 1 w/cm 2 for 15 minutes on transdermal absorption of piroxicam from solution and gel formul...

Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermatological products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to evaluate the effect of incorporating a few common penetration enhancers (in different concentrations) into a 0.5% w/w piroxicam (model drug) gel formulation, on th...