نتایج جستجو برای: Phosphoinositide

تعداد نتایج: 8581  

Journal: :Chemistry & Biology 2004

Journal: :Haematologica 2014
Elias Jabbour Oliver G Ottmann Michael Deininger Andreas Hochhaus

The phosphoinositide 3-kinase pathway represents an important anticancer target because it has been implicated in cancer cell growth, survival, and motility. Recent studies show that PI3K may also play a role in the development of resistance to currently available therapies. In a broad range of cancers, various components of the phosphoinositide 3-kinase signaling axis are genetically modified,...

Journal: :Molecular & cellular proteomics : MCP 2011
Aurélia E Lewis Lilly Sommer Magnus Ø Arntzen Yvan Strahm Nicholas A Morrice Nullin Divecha Clive S D'Santos

Considerable insight into phosphoinositide-regulated cytoplasmic functions has been gained by identifying phosphoinositide-effector proteins. Phosphoinositide-regulated nuclear functions however are fewer and less clear. To address this, we established a proteomic method based on neomycin extraction of intact nuclei to enrich for nuclear phosphoinositide-effector proteins. We identified 168 pro...

2014
Vivian R. Ericson Kerri A. Spilker Madina S. Tugizova Kang Shen

Forming the proper number of synapses is crucial for normal neuronal development. We found that loss of function of the phosphoinositide phosphatase mtm-6 results in a reduction in the number of synaptic puncta. The reduction in synapses is partially the result of MTM-6 regulation of the secretion of the Wnt ligand EGL-20 from cells in the tail and partially the result of neuronal action. MTM-6...

Journal: :Blood 2013
Sang H Min Charles S Abrams

Phosphatidylinositol and its phosphorylated derivatives, phosphoinositides, are minor constituents of phospholipids at the cellular membrane level. Nevertheless, phosphatidylinositol and phosphoinositides represent essential components of intracellular signaling that regulate diverse cellular processes, including platelet plug formation. Accumulating evidence indicates that the metabolism of ph...

2015
Kazue Kanehara Chao-Yuan Yu Yueh Cho Wei-Fun Cheong Federico Torta Guanghou Shui Markus R Wenk Yuki Nakamura Gregory P. Copenhaver

Phosphoinositides represent important lipid signals in the plant development and stress response. However, multiple isoforms of the phosphoinositide biosynthetic genes hamper our understanding of the pivotal enzymes in each step of the pathway as well as their roles in plant growth and development. Here, we report that phosphoinositide-specific phospholipase C2 (AtPLC2) is the primary phospholi...

2008
Christian Chabert Christian Rommel Thomas Rückle Nicolas Kuehn Christian Pasquali Khaled Ali Montserrat Camps Wayne P. Pearce Hong Ji Bart Vanhaesebroeck

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