To study the autophagy and mechanism of phosphatidylinositol-3-kinase/protein kinase B/mammalian target rapamycin signaling pathway in directional differentiation mesenchymal stem cells to provide basic research results for its application medical field is main objective study. The lung bone marrow mice were used as experimental materials. materials divided into five groups according settings n...

Long-term potentiation (LTP) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. Studies in recent years indicate the importance of molecular pathways in the development of memory and learning. Tropomyosin receptor kinase B (TrkB) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

Phellodendrine is a Phellodendri Cortex-derived isoquinoline alkaloids, has been shown to have various activities, especially hypoglycemic effect in mice, predicting its medicinal value on diabetes mellitus. To further understand the pharmacological of phellodendrine mellitus, network techniques used elaborate involved mechanisms. 84 common target molecules were screened, based chemical structu...

Cervical cancer belongs to the second most frequent kind of in female as well a major cause mortality all over world. MicroRNAs are crucial modulators multiple diseases. Based on GSE86100 database, microRNA-3137 expression was low cervical tissues and difference significant, thus we further probed potential along with mechanism cells. Reverse transcription-quantitative polymerase chain reaction...

Chronic rhinosinusitis is a chronic inflammatory condition that caused by many factors. However, the underlying mechanism of remains unclear. The current study focused on roles triptolide hydrogen peroxide treated nasal epithelial cells and underling mechanism. Hydrogen human were cultured different concentrations triptolide, cell growth death determined counting kit-8 flow cytometry methods. M...

Nobiletin is considered a phyto-flavonoid extracted from citrus peel and shown to several pharmacological roles such as anti-inflammatory, anti-tumor neuroprotective properties. In this study, we investigate the role of nobiletin combined docetaxel enhances apoptosis in colorectal cancer cell lines. Our results confirmed enhanced docetaxel-induced reactive oxygen species generation human carcin...

long-term potentiation (ltp) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. studies in recent years indicate the importance of molecular pathways in the development of memory and learning. tropomyosin receptor kinase b (trkb) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

The original online version of this article (Guo, R., Wang, X., Zhang, R., Shi, H., Qiao, Y., Yun, W., Ge, Lin, Y. and Lei, J. (2015) Response Subcutaneous Xenografts of Endometrial Cancer in Nude Mice to Inhibitors Phosphatidylinositol 3-Kinase/Akt Mitogen-Activated Protein Kinase (MAPK) Pathways: An Effective Therapeutic Strategy for Endometrial Cancer. Journal Therapy, 6, 1083-1092. htt...

The original online version of this article (Guo, R., Wang, X., Zhang, R., Shi, H., Qiao, Y., Yun, W., Ge, Lin, Y. and Lei, J. (2015) Response Subcutaneous Xenografts of Endometrial Cancer in Nude Mice to Inhibitors Phosphatidylinositol 3-Kinase/Akt Mitogen-Activated Protein Kinase (MAPK) Pathways: An Effective Therapeutic Strategy for Endometrial Cancer. Journal Therapy, 6, 1083-1092. htt...

The objective of this work was to identify novel downstream targets and evaluate the clinically interpretable significance long noncoding RNA KCNQ1OT1 expression in prognosis nasopharyngeal cancer. Patient with cancer (n=46) health volunteer (n=10) were collected from Beijing Army General Hospital (Beijing, China). Nasopharyngeal line 13-9B cells bought Chinese Academy Sciences Shanghai grown D...