deprotection of phosphate, phosphate, and sulfite esters by silica chloride is described. silica chloride is a mild, selective, and effective reagent for cleavage of benzyl and t-butyl esters of the above compounds.

Background: Essential oil content and composition in medicinal and aromatic plants is highly affected by both biotic and abiotic factors. Objective: To investigate the effects of drought stress, zeolite and bio-fertilizers on morphological characteristics and essential oil constituents in Dracocephalum moldavica L. Methods: This experiment was conducted in the form of split factorial based on...

An Escherichia coli mutant, DF2000, accumulates up to 0.06 M glucose 6-phosphate when supplied glucose. This extremely large concentration of intracellular glucose 6-phosphate does not serve to induce the active transport of this ester. However, if the medium is then supplemented with only 5 X 1O-4 M glucose 6-phosphate the transport system is induced. Thus, it appears that exogenous glucose 6-...

Culture Streptomyces coelicolor Muller NRRL3532 deactivates clindamycin. The inactive compound identified as clindamycin-3-phosphate on treatment with dephosphorylating enzymes affords the active compound, clindamycin. In as much as the 2-phosphate ester of clindamycin is being clinically evaluated as an injectable form of clindamycin, it was of interest to compare its in vitro and in vivo char...

Deprotection of phosphate, phosphate, and sulfite esters by silica chloride is described. Silica chloride is a mild, selective, and effective reagent for cleavage of benzyl and t-butyl esters of the above compounds.

COMPOUNDS which influence Robison ester formation from glycogen and inorganic phosphate in muscle extract may act either on the first step: glycogen + inorganic phosphate='glucose-l-phosphate (Cori ester)-or on the second step: Cori ester-+hexose-6-phosphate (Robison ester), or on both these steps. Several factors which increase or inhibit Robison ester formation could be shown to act on one or...

A factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) is a representative of the gamma-butyrolactone autoregulators that trigger secondary metabolism and morphogenesis in the Gram-positive, filamentous bacterial genus Streptomyces. Here, we report the A factor biosynthesis pathway in Streptomyces griseus. The monomeric AfsA, containing a tandem repeat domain of approximately 80 aa, cat...

Dolichyl phosphate is an intermediate in the glycosylation of N-glycosamidic linked glycoproteins in mammalian systems, and its availability may be a limiting factor in glycoprotein biosynthesis. The basic kinetics and subcellular distribution of enzymes which may influence the concentration of dolichyl phosphate in rat liver have therefore been investigated. These include dolichyl phosphate ph...

A study was conducted to determine whether repression of 3-hydroxy-3-methylglutaryl CoA reductase by a chronic high-cholesterol diet would deplete hepatic dolichol levels. Four-week-old male C57BL/6J mice were maintained on a control diet or a diet supplemented with 5% cholesterol. Animals from both groups were killed at various times and reductase activity and levels of free dolichol, dolichyl...

IN the preceding paper [Robison and Soames, 1930] it was shown that, although bone slices from rachitic animals will calcify in solutions of inorganic salts supersaturated with respect to the bone phosphate, at lower concentrations of calcium and inorganic phosphate calcification will only occur in presence of phosphoric ester. At critical concentrations of the inorganic radical as little as 0*...