نتایج جستجو برای: Phenylpyrrolidine-2,5-dione

تعداد نتایج: 359816  

Journal: :Acta Crystallographica Section E Structure Reports Online 2014

Journal: :Crystal growth & design 2014
Victor N Khrustalev Bhupinder Sandhu Samuel Bentum Alexandr Fonari Arcadius V Krivoshein Tatiana V Timofeeva

Crystal structures of racemic and homochiral forms of 2-phenylbutyramide (1) and 3-methyl-3-phenylpyrrolidine-2,5-dione (2) were investigated in detail by a single crystal X-ray diffraction study. Absolute configurations of the homochiral forms of 1 and 2, obtained by chromatographic separation of racemates, were determined. It was revealed that racemate and homochiral forms of 1 are very simil...

Journal: :Journal of the American Chemical Society 2005
Bengü Sezen Dalibor Sames

We herein describe our studies on arylation of N-phenylpyrrolidine, which led to the development of a new transformation for the direct and selective arylation of sp3 C-H bonds in the absence of a directing group. In this method, Ru(H)2(CO)(PCy3)3 4 was used as the catalyst, and preliminary mechanistic studies suggested that Ru(Ph)(I)(CO)(PCy3)2 5 is the key intermediate of the catalytic cycle....

Journal: :Acta Crystallographica Section E Structure Reports Online 2008

Journal: :Chemical communications 2014
Dagmar Scharnagel Felix Prause Johannes Kaldun Robert G Haase Matthias Breuning

A cis-2-aminomethyl-5-phenylpyrrolidine, which is easily available from methyl Boc-L-pyroglutamate, was found to be a highly efficient chiral ligand for Cu(II)-catalysed Henry reactions. Excellent yields (>90%) and superb levels of enantiocontrol (98.5-99.6% ee) were reached with aromatic, heteroaromatic, vinylic, and aliphatic aldehydes (36 examples).

Journal: :Journal of medicinal chemistry 2006
Giulio G Muccioli Johan Wouters Caroline Charlier Gerhard K E Scriba Teresa Pizza Pierluigi Di Pace Paolo De Martino Wolfgang Poppitz Jacques H Poupaert Didier M Lambert

Obesity and metabolic syndrome, along with drug dependence (nicotine, alcohol, opiates), are two of the major therapeutic applications for CB(1) cannabinoid receptor antagonists and inverse agonists. In the present study, we report the synthesis and structure-affinity relationships of 1,5-diphenylimidazolidine-2,4-dione and 1,3,5-triphenylimidazolidine-2,4-dione derivatives. These new 1,3,5-tri...

Journal: :Acta Crystallographica Section E Structure Reports Online 2008

Journal: :Journal of agricultural and food chemistry 2008
Shih-Chang Chien Miaw-Ling Chen Hsiou-Ting Kuo Yao-Ching Tsai Bi-Fong Lin Yueh-Hsiung Kuo

Six new compounds, trans-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione (1), trans-1-hydroxy-3-(4-hydroxyphenyl)-4-isobutylpyrrolidine-2,5-dione (2), cis-3-(4-hydroxyphenyl)-4-isobutyldihydrofuran-2,5-dione (3), 3-(4-hydroxyphenyl)-4-isobutyl-1H-pyrrole-2,5-dione (4), 3-(4-hydroxyphenyl)-4-isobutylfuran-2,5-dione (5), and dimethyl 2-(4-hydroxyphenyl)-3-isobutylmaleate (6), ...

Farshid Hassanzadeh, John Smith Paul Nicholls

     1,3-dialkyl 3-phenylpyrrolidine-2, 5-diones were modified to produce potential steroid sulphatase inhibitors. These modifications were aimed at producing compounds, which could be expected to bind reasonably well to the active site of the steroid sulphatase enzyme but could not be hydrolyzed readily by the enzyme due to the covalent S-C bond present. In this regard the sulphinic acid deriv...

Journal: :Acta Crystallographica Section E Structure Reports Online 2011

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