A double-blind study of 700 healthy children was done in an attempt to investigate the effectiveness of promethazine (Phenergan) with regard to the incidence and severity of ketamine-induced emergence phenomena. This study indicates that preoperative administration of Phenergan syrup is effective in reducing postoperative psychomimetic reactions, recovery time, patient apprehension, and the inc...

Servicio de Dermatología, Hospital General Universitario de Valencia, Spain in 2004 and 2005.6 The highest number of positive reactions was seen with ketoprofen (45 cases). Promethazine occupied sixth place with 7 cases, although in none of them were the reactions considered relevant. In our experience, of the 48 photopatch tests done in the Dermatology Department of Hospital 12 de Octubre in M...

In a recent article Levy (1951) records the treatment with an anti-histamine (Phenergan) of a small number of cases of infective arthritis and arthritis in Reiter's disease treated in a military hospital in Singapore. In his series of seven cases, six had a recent previous history of purulent urethritis, one having pyuria in addition, and the seventh had a recent previous history of bacillary d...

The use of antihistamine therapy in children for the management upper respiratory tract infections remains a topic debate. In this study, we focused on evaluating effectiveness promethazine (Phenergan), first-generation H1 receptor antagonist and sedative, addressing preoperative intra-operative sequelae cleft surgeries. A single-centered, parallel, randomized, double-blinded controlled clinica...

A 39 year-old male with a history of diabetes, retinitis pigmentosa, and genital warts presented with intractable occipital headaches accompanied with nausea and vomiting. The patient had markedly depressed CD4 counts. Furthermore the patient tested negative for HIV and HTLV 1/2 and had normal immunoglobulin levels. During hospital course the patient underwent a lumbar puncture and multiple ima...

Promethazine (phenergan) has two methyl groups, which in these derivatives are associated with strong antihistaminic power, while chlorpromazine is a propylamine phenothiazine, which has more marked central nervous system effects but only one-hundredth of the antihistamine potency of promezathine. The Department of Pharmacology at Oxford has pointed out (Burns, 1948; Burns and Dutta, 1948; Dews...

In this study, the combination of Phenergan C17H2ON2S, in which two aromatic rings are present, are attached to the rings at carbon position 5 and 13 halogens, and the changes in the asymmetric parameter, the convex constants, and the chemical displacement of the lateral carbon atoms are calculated. It shows that with the change of halogen based on the electrone...

Vol. 34 No. 4 • April 2009 • P&T® 175 Severe tissue damage can occur regardless of the route of parenteral administration, although IV and inadvertent intra-arterial or subcutaneous (SQ) administration results in more significant complications, including burning, erythema, pain, swelling, severe spasm of vessels, thrombophlebitis, venous thrombosis, phlebitis, nerve damage, paralysis, abscess, ...