aim: to enhance the aqueous solubility of olanzapine by using the solid dispersion technique. solid dispersions of olanzapine were prepared by the dispersion method using using pgs and ssg as carriers. drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (adp) to its platelet receptor and the subsequent adp-mediated activation of the glycoprotein gpiib/iiia complex, thereby inhibiting platelet aggregation. oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. the aim of this investigation was ...

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

this study presents the influence of hydroxypropyl-β-cyclodextrin (hpbcd) on the aqueous solubility of acyl esters of cyproterone. first, a number of esters of cyproterone were synthesized. then the phase solubility analysis of the compounds in the presence of hpbcd was investigated in phosphate buffer solution at a ph of 7.4. to gain a better understanding of the complexation mechanism, the sy...

objective(s): the aim of this work was to investigate the effect of the natural and the chemically modified form of cyclodextrins namely; β-cyclodextrin (β-cd) and hydroxypropyl-β-cyclodextrin (hp-β-cd) respectively on the solubility and dissolution rate of aripiprazole; an antipsychotic medication showing poor aqueous solubility.   materials and methods: phase solubility of aripiprazole with t...

the present work was aimed to design and develop self-nanoemulsifying drug delivery systems (snedds) with the objective to overcome the problems associated with the delivery of talinolol, a hydrophobic and poorly bioavailable drugs having ph dependant solubility. the solubility of talinolol in various oils, surfactants, cosurfactants and aqueous phases were determined to identify and select the...

      This study presents the influence of hydroxypropyl-β-cyclodextrin (HPBCD) on the aqueous solubility of acyl esters of cyproterone. First, a number of esters of cyproterone were synthesized. Then the phase solubility analysis of the compounds in the presence of HPBCD was investigated in phosphate buffer solution at a pH of 7.4. To gain a better understanding of the complexation mechanism, ...