histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. so design of new inhibitors is of great importance in pharmaceutical industries and labs. creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. this approach reduces the overall cost ass...

Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...

Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...

Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...

web search engines are one of the most popular tools on the internet which are widely-used by expert and novice users. constructing an adequate query which represents the best specification of users’ information need to the search engine is an important concern of web users. query expansion is a way to reduce this concern and increase user satisfaction. in this paper, a new method of query expa...

Nearest Neighbor (NN) searching is a challenging problem in data management and has been widely studied in data mining, pattern recognition and computational geometry. The goal of NN searching is efficiently reporting the nearest data to a given object as a query. In most of the studies both the data and query are assumed to be precise, however, due to the real applications of NN searching, suc...

the present article begins with an articulation of the significance and relation of ‘query and response’ with both dialogue and its semantic perimeters and discloses the sources of rumi’s thinking about this issue. after this taking a comparative stance, this article briefly explores the background and the significance of query and response, dialogue and dialectic as they relate to both ontolog...

vspace{0.2cm}In this paper, we design a data structure for the following problem. Let $pi$ be an $x$-monotone trajectory with $n$ vertices in the plane and $epsilon >0$. We show how to preprocess $pi$ and $epsilon$ into a data structure such that for any horizontal query segment $Q$ in the plane, one can quickly determine the minimal continuous fraction of $pi$ whose Fr{'e}chet and Hausdo...