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Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surfa...

Rapid semiquantitative elemental screening of pharmaceutical samples is described using the Agilent 7500ce ICP-MS with helium as collision gas. Polyatomic interferences are eliminated in the He pressurized cell, enabling rapid elemental profiling of pharmaceutical tablets for screening purposes. Elements which normally suffer from polyatomic interferences have been included in the semiquantitat...

There has been a significant and growing interest in chemical imaging of pharmaceutical tablets in recent years. Technology improvements and increased use has established chemical imaging as a means of providing information on certain critical quality parameters that is not readily addressable using other techniques. In addition to major pharmaceutical manufacturers, generic manufacturers and e...

Background: The surface quality of pharmaceutical tablets plays an important role, especially in the drug release of a tablet and hence affects the bioavailability of the drug. Furthermore, important tablet’s properties such as coating uniformity and mechanical integrity that can be predicted based on the known surface properties manifest the inevitable link between a tablet’s surface property ...