a simple and reliable stability-indicating rp-hplc method was developed and validated for analysis of adefovir dipivoxil (adv).the chromatographic separation was performed on a c18 column using a mixture of acetonitrile-citrate buffer (10 mm at ph 5.2) 36:64 (%v/v) as mobile phase, at a flow rate of 1.5 ml/min. detection was carried out at 260 nm and a sharp peak was obtained for adv at a reten...

gabapentin is an anticonvulsant widely used in the treatment of epilepsy. no peculiar chromophore is available on the gabapentin moiety for direct analysis by absorption spectrophotometry. a sensitive spectrophotometric method for the determination of gabapentin in bulk, pharmaceutical formulations and human plasma has been developed. in this method, gabapentin directly derivatized with vanilli...

An accurate and economical spectrophotometric method for the determination of Darunavir in pure and dosage forms has been described in the present work. Stocksolution of Darunavir was prepared by initially by dissolving 100 mg of Darunavir in 10 mL of methanol and made up to 100 mL with distilled water. The values obtained by the proposed and reference method for formulations were compared stat...

The spectrophotometric methods for the determination of Zolmitriptanin pure and dosage forms have been described in thispaper. The aim of the present work is to develop simple, sensitive and cost-effective spectrophotometric method for the determination of Zolmitriptan in pharmaceutical formulation. The present methods involve the determination of Zolmitriptanin pharmaceutical dosage at the giv...

The advantages of the therapeutic profile of quetiapine have led to increasing use in the clinical practice, which encourages the development of new analytical method to provide driving force in today’s pharmaceutical industry. Higher sample throughput with more information per sample may decrease the time to market, an important driving force in today’s pharmaceutical industry [1-3]. UPLC is a...

discussion while this novel type of drug delivery is known as a suitable substitute for oral and parenteral administration, it was well accepted and extensively mentioned in persian medical and pharmaceutical manuscripts and other traditional systems of medicine as well. accordingly, medieval pharmaceutical standpoints on nasal dosage forms could still be an interesting subject of study. theref...