BACKGROUND In general, organic solvents are inhibiting many physiological enzymes and alter the behavioural functions, but the available scientific knowledge on laboratory solvent induced organ specific toxins are very limited. Hence, the present study was planned to determine the sub-chronic toxic effects of petroleum ether (boiling point 40-60°C), a laboratory solvent in Sprague-Dawley (SD) r...

Background and objectives: Withania coagulans Dunal (Solanaceae) fruits are recommended to treat asthma, dyspepsia, biliousness, flatulent colic, liver complaints, intestinal infections, strangury, wounds and as diuretic, emetic and sedative agent in Indian traditional system of medicine. The objective of this study was to describe the systematic fatty acid composition...

Shade dried leaves of Ficus carica were extracted using petroleum ether (60-80 degrees ) and tested for antihepatotoxic activity on rats treated with 50 mg/kg of rifampicin orally. The parameters assessed were serum levels of glutamic oxaloacetate transaminase, glutamic pyruvic transaminase, bilirubin and histological changes in liver. Liver weights and pentobarbitione sleeping time as a functi...

Background & Aims: Teucrium polium (TP) is amongst the commonly used remedies in traditional medicine. Some reports have claimed hepatotoxicity of TP but other reports have not supported it. This study was designed to evaluate the probable hepatotoxicity of TP. Methods: Petroleum ether fraction of TP was dissolved in DMSO and the final concentration was adjusted by diluting in physiologic salin...

OBJECTIVES The aim of the present work was to study the anti-inflammatory and anti-arthritic activities of petroleum ether extract of fenugreek seeds. MATERIALS AND METHODS Fenugreek seed powder was extracted in petroleum ether by cold maceration. This fenugreek seed petroleum ether extract (FSPEE) was analyzed by gas-liquid chromatography (GLC) and tested on rats against carrageenan and form...

The present study explores the hepatoprotective activity of various extracts of Ferula asafoetida, Momordica charantia Linn and Nardostachys jatamansi against experimental hepatotoxicity. Polyherbal suspensions were formulated using extracts showing significant activity and evaluated for both physicochemical and hepatoprotective activity in comparison with LIV-52 as standard. Petroleum ether (6...

OBJECTIVES The present study investigated the toxic properties of petroleum ether extract of Wattakaka (W.) volubilis in Wistar female rats. METHODS An in vitro brine shrimp lethality bioassay was studied in A. Salina nauplii, and the lethality concentrations were assessed for petroleum ether extract of W. volubilis. A water soluble portion of the test extract was used in different concentrat...

Petroleum ether extract of Caesalpinia bonduc L. (Roxb) seeds (Family: Caesalpiniaceae) was evaluated for its anti-inflammatory activity in rats. Wistar rats (120-150 g) of either sex were pretreated with petroleum ether extract of seed kernel of C. bonduc. Inflammation was induced in rat paw by injecting 0.1 ml of carrageenan (1% w/v) in subplantar region of right hind paw. Inflammation induce...

This study was performed to determine the usefulness of the intercellular metabolic cooperation assay for analysis of a complex mixture and to compare the results obtained with previously conducted in vivo tumor promoter assays. One hundred 2R1 cigarettes were smoked according to Federal Trade Commission guidelines and the resulting condensate was separated into a water/methanol-soluble fractio...

objectives: this study was designed to investigate the potential phyllanthus niruri extracts in promotion of hair growth. materials and methods: here, we studied the hair growth promoting activity of petroleum ether extract of p. niruri following its topical administration. alopecia was induced in albino rats by subcutaneous administration of testosterone for 21 days. evaluation of hair loss in...