the aim of the present study was to investigate the influence and the mechanisms of cineoleand terpineol on the in-vitro transdermal delivery of huperzine a from microemulsions, andtheir potential synergistic effect on the permeation enhancement. the transdermal deliveryof huperzine a from microemulsions with different concentrations of cineole and terpineolthrough the rat abdominal skin was de...

preformulation studies on transdermal dosage forms involve liberal use of animal skin for assessing the permeation characteristics of drugs, influence of permeation enhancers, optimizing the formulation variables etc. the restricted availability of animal skin due to concerns regarding prevention of cruelty to animals has generated considerable interest in developing polymeric films for use as ...

the purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (ss) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. the influence of various permeation enhancers, such as dimethyl sul...

many properties of chemicals depend on their stereochemistry. among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. we have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. as, depending on their lipophilicity, penetration enhancers can change ...

in this work we sought to determine whether vesicles (liposomes/niosomes) were able to enhance finasteride concentration in the dermis layer, including the pilosebaceous units (psu). such enhancement could be beneficial in the treatment of some androgen-related skin disorders. hamster flank skin was used to study  3hfinasteride permeation via vesicles and a hydroalcoholic solution (ha). the dru...

Although permeation of hydrocarbons such as Benzene, Toluene, Ethybenzene, and Xylene (BTEX) through polyethylene (PE) pipe in potable water applications is rarely occurred. It is important to understand permeation mechanism and characterize the potential health risk. The most common potential hydrocarbon substances are originated from gasoline leaks. Previous research has shown that pipe mater...

comNode classification within Membrane Residue Curves (M-RCMs) currently hinges on Lyapunov’s Theorem and therefore the computation of mathematically complex eigenvalues. This paper presents an alternative criterion for the classification of nodes within M-RCMs based on the total membrane flux at node compositions. This paper demonstrates that for a system exhibiting simple permeation behaviour...

objective(s):drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. analgesics such as nsaids have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. meloxicam is one of nsaids with no topical form in the market. in this research, we attempted to quantify the skin permeation of a m...

Permeation tubes are convenient analyte sources for generating standard gas mixtures (containing, in particular, volatile organic compounds) used in the calibration of analytical instruments. For small permeation rates, corresponding to trace levels of analytes, the calibration of permeation tubes is time-consuming. The use of thermogravimetry as a means to measure rapidly the weight loss at co...