Background Tolnidamine-induced changes have been reported earlier on spermatogenesis, fertility and sperm count in rat, rabbit and langur monkey. The aim of this study is to assess the response of these aspects to tolnidamine in the laboratory mouse. MaterialsAndMethods Adult male mice (12-14 weeks old) of Parkes (P) strain were used in the present study. All the animals were divided into five ...

S permatogenesis refers to the process by which the production and development of the spermatozoa (the mature male gamete of most sexually reproducing species) occurs. It is a complex, stepwise process of sperm development, taking more than a month depending upon the species involving three specific functional phases: spermatogonial proliferation, meiosis and metamorphosis. Investigators have b...

S permatogenesis is a tightly regulated process of development for the generation of mature spermatozoa. Mammalian spermatogenesis occurs in the convoluted seminiferous tubules of the testes, where spermatogenic stem cells (SSCs) reside on sustentacular Sertoli cells of somatic origin, forming a germinal epithelial structure. Spermato genesis is accomplished in a complicated, timely controlled ...

Two self-sterile mutations that define the spermatogenesis-defective gene spe-I 7 have been analyzed. These mutations affect unc-22 and fail to complement each other for both Unc-22 and spermatogenesis defects. Both of these mutations are deficiencies (hcDfl and hDfl3) that affect more than one transcription unit. Genomic DNA adjacent to and including the region deleted by the smaller deficienc...