نتایج جستجو برای: Pentobarbital

تعداد نتایج: 2674  

Journal: :The Journal of pharmacology and experimental therapeutics 1976
I K Ho

Rapid tolerance development to pentobarbital by pentobarbital pellet implantation was evidenced by a decrease in sleeping time after challenge with different doses of sodium pentobarbital ranging from 37.5 to 100 mg/kg i.p. or a fixed dose of 75 mg/kg i.p. of the drug. The sleeping time produced by sodium pentobarbital decreased by 50% after 1 day. After 2 or 3 days of implantation, the sleepin...

Journal: :Journal of neurocritical care (Print) 2023

Background: Barbiturate poisoning is rare but potentially fatal. Case Report: We reported a case of barbiturate in 28-year-old woman who recovered from lethal pentobarbital deliberate self-poisoning. The initial blood concentration was 61 mg/L, corresponding to dose. Despite the ingestion high dose pentobarbital, electroencephalogram revealed an unattended pattern compatible with possible nonco...

G. Heidari-Hamedani M. Emamghoreishi

Background: Coriandrum sativum L. has been recommended for relief of insomnia in Iranian traditional medicine. However, no pharmacological studies have yet evaluated its sedative effects. The aim of this study was to determine if extracts and essential oil of coriander seeds have sedative-hypnotic activity. Methods: The aqueous or hydro-alcoholic extracts or essential oil of coriander seeds (10...

Journal: :PloS one 2016
Alexis M Ziemba Stuart A Forman

BACKGROUND Pentobarbital, like propofol and etomidate, produces important general anesthetic effects through GABAA receptors. Photolabeling also indicates that pentobarbital binds to some of the same sites where propofol and etomidate act. Quantitative allosteric co-agonist models for propofol and etomidate account for modulatory and agonist effects in GABAA receptors and have proven valuable i...

Journal: :jundishapur journal of natural pharmaceutical products 0
azar hosseini pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, ir iran fatemeh forouzanfar student research committee, faculty of medicine, mashhad university of medical sciences, mashhad, ir iran; department of pharmacology, school of medicine, mashhad university of medical sciences, mashhad, ir iran hassan rakhshandeh pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, ir iran; department of pharmacology, school of medicine, mashhad university of medical sciences, mashhad, ir iran; pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, ir iran. tel: +98-5118828566, fax: +98-5118828567

background insomnia or sleeplessness is a disorder characterized by a personal incapability to falling or staying asleep for a desirable period of time, therefore disturb in quality of life. objectives the present study was carried out to investigate the effect of hydro-alcoholic extract of nepeta glomerulosa and its fractions on sleep-prolonging. materials and methods the extract and its fract...

Journal: :Stroke 1978
K L Black D J Weidler N S Jallad T M Sodeman G D Abrams

The efficacy of pentobarbital in the delayed treatment of acute cerebral ischemia was investigated in cats. Cerebral ischemia was produced by left middle cerebral artery (LMCA) ligation. Ten cats received 50 mg/kg of pentobarbital prior to ligation; a second group of 10 cats received the same dose of pentobarbital 2 hrs after ligation, and the control group of 7 cats received no pentobarbital. ...

2002
Mustapha Irnaten Wendy M. Walwyn Jijiang Wang Kyoung S. K. Chang Michael C. Andresen

Background: Pentobarbital decreases the gain of the baroreceptor reflex on the order of 50%, and this blunting is caused nearly entirely by decreasing cardioinhibitory parasympathetic activity. The most likely site of action of pentobarbital is the -aminobutyric acid type A (GABAA) receptor. The authors tested whether pentobarbital augments the inhibitory GABAergic neurotransmission to cardiac ...

Journal: :Molecular pharmacology 2000
M Eghbali P W Gage B Birnir

We examined the effect of a range of pentobarbital concentrations on 0.5 microM gamma-aminobutyric acid (GABA)-activated channels (10 +/- 1 pS) in inside-out or outside-out patches from rat cultured hippocampal neurons. The conductance increased from 12 +/- 4 to 62 +/- 9 pS as the pentobarbital concentration was raised from 10 to 500 microM and the data could be fitted by a Hill-type equation. ...

2011
Jae-Wook Kim Jin-Yi Han Jin Tae Hong Rihua Li Jae Soon Eun Ki-Wan Oh

Dried Chrysanthemum morifolium flowers have traditionally been used in Korea for the treatment of insomnia. This study was performed to investigate whether the ethanol extract of Chrysanthemum morifolium flowers (EFC) enhances pentobarbital-induced sleep behaviors. EFC prolonged sleep time induced by pentobarbital similar to muscimol, a GABA(A) receptors agonist. EFC also increased sleep rate a...

Journal: :iranian journal of pharmaceutical research 0
h rakhshandah m hosseini k dolati

rosa damascena (rosaceae) has been found to act on central nervous system including the brain. several studies confirm that rosa damascena inhibits the reactivity of the hypothalamus and pituitary systems in rat and can suppress the reactivity of central nervous system. in traditional medicine the hypnotic effect of rose is also suggested. in the present study hypnotic effect of ethanolic, aque...

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