نتایج جستجو برای: Pasylation
تعداد نتایج: 14 فیلتر نتایج به سال:
Although antigen-binding fragments (Fabs) of antibodies constitute established tracers for in vivo radiodiagnostics, their functionality is hampered by a very short circulation half-life. PASylation, the genetic fusion with a long, conformationally disordered amino acid chain comprising Pro, Ala and Ser, provides a convenient way to expand protein size and, consequently, retard renal filtration...
A major limitation of biopharmaceutical proteins is their fast clearance from circulation via kidney filtration, which strongly hampers efficacy both in animal studies and in human therapy. We have developed conformationally disordered polypeptide chains with expanded hydrodynamic volume comprising the small residues Pro, Ala and Ser (PAS). PAS sequences are hydrophilic, uncharged biological po...
Both insufficient plasma half-life (circulation for only few hours or less) and laborious downstream purification can be bottlenecks biological drug development. We report a novel strategy the efficient gentle affinity of pharmacologically relevant proteins modified by PASylation prolonged action in vivo . previously described antibodies specific Pro/Ala-rich sequences (PAS) covering range bind...
level: intermediate Since the 1985 approval of the first recombinant human growth hormone (hGH, such as Protropin/somatrem human growth hormone from Genentech, now Roche), the number of clinical indications for therapy with hGH has steadily increased (1). That led to a highly successful drug with more than US$3 billion sales in 2011 (2). Even so, hGH shares a common problem with most other firs...
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