introduction: lead (pb) is a neurotoxin that its different effects on the central nervous system are well-known. previous studies have reported the potent effects of vitamin c on memory.the present study was undertaken to evaluate the protective effects of vitamin c against leadinduced amnesia. methods: male wistar rats were divided into 4 groups: the control (saline), negative control (lead), ...

introduction: cholinergic systems are involved in learning and memory. scopolamine, a muscarinic acetylcholine receptor antagonist, is used as a standard/ reference drug for inducing cognitive deficits in healthy humans and animals. the purpose of this study was to evaluate the effects of scopolamine on avoidance memory and number of neurons in rat’s hippocampus. . methods: thirty five male alb...

background: it has been reported that epilepsy is a disorder of the central nervous system that causes memory impairment. this study examines the role of the aqueous extract of boswellia on the learning disability of the pentylenetetrazol (ptz)‑induced kindled rats. methods: in this experimental study, 64 male rats were used. kindling seizures were induced by three injections of 25 mg/kg of ptz...

background: studies have shown that individuals with fertility problems experience psychosocial problems. the use of various coping strategies seems to have different impacts on women with infertility stress. the aim of this study was to examine the role of coping strategies (active-avoidance, passive-avoidance, active-confronting and meaning based) in predicting infertility stress among a grou...

introduction: neurohormones like testosterone and estradiol have an important role in learning and memory. the hippocampus is essentially involved in learning and memory, and is known to be a target for estradiol actions. estrogen receptors (ers) are highly expressed in ca1 of rat hippocampus, and mediate the effects of estrogen on learning and memory. estradiol receptor belong to a family of t...

alzheimer’s disease (ad) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. pelargonidin (pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. this study was designed to assess pel memory enhancing effects on the a rat amyloid beta 25-35 (aβ) intrahippocampal microinjections model of ad in...

introduction mdma or ecstasy is a derivative of amphetamines used mostly by young people worldwide. although the acute effects of this drug are known, the effect of chronic administration is not well studied. therefor the aim of this study was to determine the effects of repeated (long term) administration of mdma on rats' memory and their hippocampal cell density. method: young adult male...

there are several conflicting evidences showing the effect of morphine on learning and memory processes. in the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using passive avoidance shuttle box and morris water maze tasks were investigated, respectively. male rats received morphi...

objective(s): auraptene (7-geranyloxycoumarin) (aur), from citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (ache) and beta-secretase inhibitory effects. scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of alzheimer’s disease (ad). this research aimed to investigate ...

objective(s) the present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme q10 (coq10) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (icv-stz), an animal model of sporadic type of alzheimer's disease. materials and methods the lesion groups were injected bilaterally with icv-stz (1.5 mg/kg b.wt., in no...