Partially liquefied vitreous humor is a common physical and biochemical degenerative change in vitreous body which the liquid component gets separated from collagen fiber network and leads to form a region of liquefaction. The main objective of this research is to investigate how the oscillatory motions influence flow dynamics of partial vitreous liquefaction (PVL). So far computational fluid d...

The aim of the study is to clarify the vitreous body structure and liquefaction phenomena. It was found that when melting a frozen rabbit vitreous body, the gel-sol transition phenomenon occurs and the gel structure is broken. This is almost like the liquefaction of the vitreous body in vivo. We try to clarify the liquefaction phenomenon by using this animal model. The native vitreous body has ...

PURPOSE Vitrectomy is associated with the rapid progression of nuclear cataracts. This study was conducted to test the hypothesis that age-related liquefaction of the vitreous gel may also be associated with lens opacification. METHODS Lenses from eye bank eyes were graded for nuclear, cortical, and posterior subcapsular opacities, and the amount of liquid vitreous was measured. RESULTS Nuc...

PURPOSE The effects of vitreous liquefaction in the elderly on the distribution of drugs from intravitreal injections, depots, or devices remains unclear. The purpose of the present study was to develop a liquefied vitreous model that simulates the aged condition, to enable the study of clinically relevant drug distribution. METHODS Dutch-belted rabbits were used to develop a study model usin...

To determine the mechanisms of vitreous liquefaction following vitreous hemorrhage, we investigated the effects of the free radicals produced by a bilirubin-sensitized photochemical reaction on collagen and hyaluronic acid (HA). Bovine vitreous collagen and HA were irradiated by visible light in the presence of bilirubin, which is produced from the degradation of hemoglobin, as a photosensitize...

BACKGROUND Vitreous degeneration begins soon after birth and accelerates throughout life. Vitreous liquefaction with a slowly progressive separation of the posterior hyaloid from the peripheral macula usually leads to complete posterior vitreous detachment. The purpose of this study is to measure the age-related prevalence of partial vitreous separation and the length of residual vitreous adhes...

Research in the pathophysiology of retinal detachments would be aided if an experimental model of such a lesion could be achieved. In an attempt to produce such a model, it was felt essential to cause vitreal as well as retinal alterations. This role of vitreoretinal adhesions and liquefaction of the vitreous as the two main anatomic factors in the etiology of the idiopathic type of retinal det...

PURPOSE Aging of the vitreous body can result in sight-threatening pathology. One aspect of vitreous aging is liquefaction, which results from the vanishing of collagen fibrils. We investigated the possibility that trypsins are involved in vitreous type II collagen degradation. METHODS Immunohistochemistry and western blotting were used for detecting and locating trypsin isoforms in the vitre...

PURPOSE To investigate the vitreous findings in patients with cicatricial retinopathy of prematurity (ROP) who underwent retinal cryopexy and/or photocoagulation during the acute phase of the disease. METHODS Vitreous findings were evaluated in 15 patients (29 eyes) with cicatricial ROP by slit-lamp biomicroscopy and indirect ophthalmoscopy. RESULTS The ocular examination revealed that all ...

PURPOSE To determine whether aging vitreous collagen fibrils undergo ultrastructural changes that might underlie vitreous liquefaction and posterior vitreous detachment. METHODS Vitreous collagen fibrils from 21 human subjects (age range, 3-89 years) and from bovine eyes were isolated on electron microscopy grids. Cupromeronic blue labeling in the presence of 0.3 M MgCl(2) and immunogold labe...