Objective: To investigate the cumulative recurrence rate of pars tensa retraction cholesteatoma on the new staging system established by Japan Otological Society (JOS). Materials and Methods: It is a retrospective study and performed in a tertiary and academic center. The series comprised 71 patients with pars tensa retraction cholesteatoma who underwent surgical treatment by a single surgeon b...

Seventy-three cases of adult cholesteatoma, including 52 cases with pars flaccida type cholesteatoma and 21 with pars tensa type cholesteatoma, were examined using high resolution computed tomography, in both axial (lateral semicircular canal plane) and coronal sections (cochlear, vestibular and antral plane). These cases were classified into two subtypes according with the presence of extensio...

Aural cholesteatoma is characterized by invading squamous epithelia with altered growth properties. Cytokeratin (CK) expression is affected in epidermal proliferative diseases and represents the alterations of keratinocyte proliferation, differentiation, and migration. In the present study, the intensity of CK immuno-expression was determined, using densitometry at various sites in experimental...

In order to provide a basis for meaningful exchange of information among those treating cholesteatoma, the Committee on Nomenclature of the Japan Otological Society (JOS) was appointed in 2004 to create a cholesteatoma staging system as simple as possible to use in clinical practice in Japan. Following the announcement of preliminary criteria for the staging of pars flaccida (attic) cholesteato...

INTRODUCTION Children cholesteatoma have been shown to demonstrate aggressive growth with greater extension and higher rates residual and recurrent disease compared with adults, due to anatomic and physiologic differences. AIM This study aimed to determine the clinical and pathological features of cholesteatoma in young children less than 7 years of age. MATERIAL AND METHODS Retrospective r...

OBJECTIVES/HYPOTHESIS Although the migration of its squamous outer surface of the tympanic membrane has been well characterized, there is a paucity of data available concerning the migratory behavior of its medial mucosal surface. Existing theories of primary acquired cholesteatoma pathogenesis do not adequately explain the observed characteristics of the disease. We propose a new hypothesis, b...

The sequence of eustachian tube (ET) dysfunction leading to negative pressure and progressive tympanic membrane (TM) retraction has long been implicated as one of the most plausible hypotheses in the pathogenesis of acquired cholesteatoma.1,2 The objective of this case report is to notify on a patient with a pars tensa cholesteatoma, whose development was closely related to an aberrant course o...

Congenital cholesteatoma (CC) is a whitish mass lesion found in the middle ear cleft behind intact tympanic membrane early life. It relatively uncommon disease and shows its growth extension over period of time. CC evidenced with no prior history perforation, otorrhea, previous otologic procedures, normal pars tensa, flaccida. The etiopathogenesis still controversial; however, epithelial cell r...

IMPORTANCE Several classifications of cholesteatoma exist, but there are controversies about their clinical application. OBJECTIVE To classify cholesteatomas and describe the prevalence of the subtypes. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional comparative study of 414 ears in 356 consecutive patients with middle ear cholesteatoma and no history of ear surgery treated at a tertiar...