In order to ensure the safety of parenterals, international pharmacopoeias and national standards have set up stringent guidelines and standards. Particulate con- tamination is a potential health risk caused by intravenous injection of particles large enough to potentially clog the small arteries. Particles could be produced through manufacturing and packaging or even dispensing of the ph...

in order to ensure the safety of parenterals, international pharmacopoeias and national standards have set up stringent guidelines and standards. particulate con- tamination is a potential health risk caused by intravenous injection of particles large enough to potentially clog the small arteries. particles could be produced through manufacturing and packaging or even dispensing of the pharmace...

OBJECTIVES To evaluate microbial contamination rates of low- and medium-risk level media fill tests performed by pharmacy students near the beginning and end of a parenterals laboratory course in the second- professional year of a doctor of pharmacy (PharmD) program. METHODS Students enrolled in a required parenterals laboratory class (N = 84) participated in this study. The aseptic technique...

TOPIC: Education, Research, and Quality Improvement TYPE: Original Investigations PURPOSE: Parenteral fluid intake in acute care is typically consists of bolus maintenance IV fluids, parenteral nutrition, diluent considerations for medications. The hidden contribution from small volume parenterals (SVP) medications (e.g. antibiotics, antifungals, antivirals, chemotherapy, chemotherapy support d...

Development, validation and applications of the in vitro pyrogen test (IPT) based on human whole blood (submitted to J Clin Immunol) International validation of novel pyrogen tests based on human monocytoid cells. on cryopreserved human whole blood for lipidic parenterals (Pharmeuropa, in print) on cryopreserved human primary blood cells (J Immunol Methods, in print) Comparison of the reactivit...

This paper will outline the advantages of utilizing gamma radiation as a means for terminally sterilizing parenterals and other pharmaceutical products. The factors which must be evaluated in order to qualify a product for radiation sterilization will be detailed. It will also compare the characteristics of this method with other technologies currently available. The highest SAL can be achieved...