Thirty one patients with biologic and clinical diagnosis of hyperparathyroidism were submitted to thalium-technetium scan prior to exploration of the neck. Scan findings were compared with the pathologic results. Surgical exploration of the neck showed a parathyroid adenoma in 24 patients, parathyroid carcinoma in one patient, normal parathyroid in another patient and parathyroid hyperplasia in...

thirty one patients with biologic and clinical diagnosis of hyperparathyroidism were submitted to thalium-technetium scan prior to exploration of the neck. scan findings were compared with the pathologic results. surgical exploration of the neck showed a parathyroid adenoma in 24 patients, parathyroid carcinoma in one patient, normal parathyroid in another patient and parathyroid hyperplasia in...

Secondary hyperparathyroidism is characterised by excessive secretion of parathyroid hormone and parathyroid hyperplasia, resulting in both skeletal and extraskeletal consequences. Recent basic and clinical studies have brought considerable advances in our understanding of the pathophysiology of parathyroid hyperplasia and have also provided practical therapeutic approaches, especially with reg...

introduction: radio-guided parathyroid surgery along with other minimally invasive surgeries constitutes the main surgical treatment procedures for different kinds of hyperparathyroidism.  in this article we have reported our experience of radio-guided parathyroid surgery using tc-99m sestamibi. methods: ten patients with hyperparathyroidism included in our study. twenty mci of tc-99m sestamibi...

  Introduction: Radio-guided parathyroid surgery along with other minimally invasive surgeries constitutes the main surgical treatment procedures for different kinds of hyperparathyroidism.  In this article we have reported our experience of radio-guided parathyroid surgery using Tc-99m sestamibi. Methods: Ten patients with hyperparathyroidism included in our study. ...

BACKGROUND In chronic kidney disease (CKD), parathyroid hyperplasia contributes to high serum parathyroid hormone (PTH) and also to an impaired suppression of secondary hyperparathyroidism by calcium, vitamin D and fibroblast growth factor 23 (FGF23). In rats, systemic inhibition of epidermal growth factor receptor (EGFR) activation markedly attenuated uremia-induced parathyroid hyperplasia and...

OBJECTIVE Dual-phase (99m)Tc-sestamibi (methoxyisobutylisonitrile [MIBI]) imaging is the technique of choice for hyperparathyroidism (HPT), especially for localizing parathyroid adenomas. Prior studies have shown its utility for detecting hyperplasia is equivocal, but we believe this is not true. We attempted to quantitate the region-of-interest counts per pixel between immediate images and del...

BACKGROUND Secondary hyperparathyroidism (sHPT) represents an adaptive response to progressively impaired control of calcium, phosphorus and vitamin D in chronic kidney disease (CKD). It is characterized by parathyroid hyperplasia and excessive synthesis and secretion of parathyroid hormone (PTH). Parathyroid hyperplasia in uremic rats can be prevented by calcium-sensing receptor (CaSR) activat...

INTRODUCTION: HGF (Hepatocyte Growth Factor), TGFb1 (Transforming Growth Factor b1) and IGF-I (Insulin Like Growth Factor I) are cytokines that are involved in the parathyroid tumors formation and growth. We tried to determine, if there are changes and relationships in the production of these cytokines by tumor cells of parathyroid tumors. MATERIAL AND METHODS: We determined concentrations of H...

The pathogeneses of parathyroid disease in patients with uremia and nonfamilial primary parathyroid hyperplasia are poorly understood. Because of multigland involvement, it has been assumed that these common diseases predominantly involve polyclonal (non-neoplastic) cellular proliferations, but an overall assessment of their clonality has not been done. We examined the clonality of these hyperp...