oxidative stress is involved in the pathogenesis of asthma. paraoxonase 1 (pon1) and arylesterase are esterase enzymes displaying antioxidant characteristics. pon1 activity varies widely among individuals and ethnic groups, partly related to polymorphisms. the aim of this study was to determine the activities of pon1 and arylesterase including the phenotype distribution of pon1 in asthmatic pat...

human serum paraoxonase (hupon1:   ec 3.1.8.1), a calcium-dependent esterase, is synthesized in the liver and   widely distributed in tissues including liver, kidney, intestine, and serum,   where it is associated exclusively with high-density lipoprotein.  human paraoxonase-1 plays an important role   in prevention of atherosclerosis and also protection against organophosphate-induced   neurot...

BACKGROUND Apolipoprotein A-1, paraoxonase-1 and paraoxonase-3 are antioxidant and anti-atherosclerotic structural high-density lipoprotein proteins that are mainly synthesized by the liver. No study has ever been performed to specifically examine the effects of caffeine on paraoxonase enzymes and on liver apolipoprotein A-1 protein levels. AIMS To investigate the dose-dependent effects of ca...

OBJECTIVE The purpose of this study was to analyze the consequences of HDL oxidation for paraoxonase-1 metabolism and function. METHODS AND RESULTS HDL was oxidized with AAPH, copper ions, and hypochlorite. Secretion studies were performed using human paraoxonase-1-transfected cells lines and primary rat hepatocytes. Stability studies were performed with recombinant paraoxonase. Conditioned m...

background: arsenic as an environmental toxicant is able to induced oxidative stress. the present study aimed to evaluate of vitamin c supplementation on the paraoxonase1 (pon1) arylesterase activity (responsible for hydrolysing lipid-peroxides) in rat exposed to arsenic. methods: the study was conducted in the faculty of veterinary medicine, tabriz islamic azad university, tabriz, iran in 2001...

BACKGROUND Recently another member of the paraoxonase gene family designated paraoxonase-2 has been identified. Paraoxonase-2 has antioxidant properties similar to paraoxonase-1 and paraoxonase-3. However, in contrast to paraoxonase-1 and paraoxonase-3, paraoxonase-2 is not associated with high-density lipoprotein and may only exert its antioxidant function at the cellular level. METHODS We a...

the oxidation of low-density lipoproteins and cell membrane lipids is believed to play an integral role in the development of fatty streak lesions, an initial step in coronary artery disease (cad). paraoxonase-1 (pon1) is an enzyme associated with the high-density lipoprotein (hdl) particle. pon1 protects ldl from oxidative modification by hydrolyzing lipid peroxides, suggestive of a role for p...