in the present work, the modified nickel electrode was electrochemically fabricated and tested for the electro-oxidation of paracetamol in alkaline media. the methods of cyclic voltammetry (cv), chronoamperometry (ca), and impedance spectroscopy (eis) were used to determine kinetic parameters such as transfer coefficient (α), the catalytic reaction rate constants (k), and the diffusion coeffici...

paracetamol that is known as acetaminophen have the most consume as an analgesic and antipyreticdrug in the world. that is formulated in single compound or mixture at many forms such astablets, syrups, suspensions and drops. the last form is intravenous injections. paracetamol derivedfrom 4-minophenol which is synthesized by acylated the p-acetaminophenol and acetic anhydride.4-aminophenol is t...

Paracetamol that is known as acetaminophen have the most consume as an analgesic and antipyreticdrug in the world. That is formulated in single compound or mixture at many forms such astablets, syrups, suspensions and drops. The last form is intravenous injections. Paracetamol derivedfrom 4-minophenol which is synthesized by acylated the P-acetaminophenol and acetic anhydride.4-aminophenol is t...

pain in icu patients should be managed effectively and safely. fentanyl and paracetamol are used frequently in icu. however experience using iv paracetamol in the setting of critically ill patients is limited. we evaluated the analgesic effect and adverse reactions of intravenous paracetamol compared to fentanyl in icu patients with mild to moderate pain. forty patients in a general icu were ra...

Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compared to Fentanyl in ICU patients with mild to moderate pain. Forty patients in a general ICU were ra...

Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compared to Fentanyl in ICU patients with mild to moderate pain. Forty patients in a general ICU were ra...

Paracetamol (acetaminophen) is one of the most commonly used drugs for the treatment of pain and fever in children, both at home and in the clinic, and is now also found in the environment. Paracetamol is known to act on the endocannabinoid system, involved in normal development of the brain. We examined if neonatal paracetamol exposure could affect the development of the brain, manifested as a...

Paracetamol (acetaminophen) is widely used as an over-the-counter analgesic and antipyretic drug. The aim of this study was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β-glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative stress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure o...

OBJECTIVE To assess whether measuring plasma paracetamol concentrations in all patients with drug overdose or collapse (altered consciousness) changes outcome. METHOD A retrospective survey was performed of all patients attending the Accident and Emergency Department at Guy's Hospital, London over a 12 month period who had plasma paracetamol concentrations measured (it is hospital policy that...