in the present work, the modified nickel electrode was electrochemically fabricated and tested for the electro-oxidation of paracetamol in alkaline media. the methods of cyclic voltammetry (cv), chronoamperometry (ca), and impedance spectroscopy (eis) were used to determine kinetic parameters such as transfer coefficient (α), the catalytic reaction rate constants (k), and the diffusion coeffici...

Paracetamol is a non-steroidal anti-inflammatory drug used as an antipyretic agent for the alternative to aspirin. Conversely, the overdoses of paracetamol can cause hepatic toxicity and kidney damage. Hence, the determination of paracetamol receives much more attention in biological samples and also in pharmaceutical formulations. Here, we report a rapid<span id="transmark" style="display: non...

An electrochemical sensor based on the electrocatalytic activity of functionalized graphene for sensitive detection of paracetamol is presented. The electrochemical behaviors of paracetamol on graphene-modified glassy carbon electrodes (GCEs) were investigated by cyclic voltammetry and square-wave voltammetry. The results showed that the graphene-modified electrode exhibited excellent electroca...

In the present work, the modified nickel electrode was electrochemically fabricated and tested for the electro-oxidation of paracetamol in alkaline media. The methods of cyclic voltammetry (CV), chronoamperometry (CA), and impedance spectroscopy (EIS) were used to determine kinetic parameters such as transfer coefficient (α), the catalytic reaction rate constants (k), and the diffusion coeffici...

An accurate, simple, reproducible and sensitive method for the determination of Paracetamol and Codeine phosphate was developed and validated. Paracetamol and Codeine were separated by HPLC using a LiChrospher® RP-18 column and isocratic elution with a flow rate of 1.0 ml/min. Mixture of Acetonitile with Buffer solution (pH=2.5) (15:85) was used as mobile phase. The detection was at 210 nm wave...

A rapid and sensitive high performance liquid chromatography with UV detection method was developed and validated for the quantification of paracetamol, chlorzoxazone and aceclofenac in dosage forms. The chromatographic separation was carried out on a Phenomenex Luna C18 column using a mixture of acetonitrile-0.05M disodium hydrogen orthophosphate (65:35) (pH adjusted to 3.0 using 10% orthophos...

AIM The objective of the study was to develop simple RP-HPLC method for the simultaneous determination of paracetamol and lornoxicam without prior separation. MATERIALS AND METHODS In this method, Kromasil C8 (250 mm, 4.6 mm, 5 μm) column was used. The mobile phase used was methanol:phosphate buffer (60:40, v/v, pH 6.4), at flow rate of 1 ml min(-1). UV detection was monitored at 302 nm. RE...

A spectrophotometric flow injection method for the determination of paracetamol in pharmaceutical formulations is proposed. The procedure was based on the oxidation of paracetamol by sodium hypochloride and the determination of the excess of this oxidant using o-tolidine dichloride as chromogenic reagent at 430 nm. The analytical curve was linear in the paracetamol concentration range from 8.50...

A spectrofluorimetric method for the determination of paracetamol is presented, based on the oxidation of the analyte to give the fluorophore 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl. Sodium hypochlorite was used as an oxidizing reagent and the optimum pH was found to be 10.0 (sodium carbonate-boric acid buffer solution). The linear concentration range of application was 0.1-100.0 micrograms...

A sensitive electroanalytical method for determination of acetaminophen (ACT) in paracetamol tablet has been developed and validated. Cyclic voltammetry (CV) was used to study the electrochemical behaviour of paracetamol, while differential pulse voltammetry (DPV) was used to determine ACT. Screen printed carbon electrode was used for the analysis. Determination of all parameters in paracetamol...